Clinical Trial
Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors.
Investigator
Complete title:
A PHASE 1 DOSE ESCALATION AND EXPANSION STUDY EVALUATING THE SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ANTITUMOR ACTIVITY OF PF 07257876 IN PATIENTS WITH ADVANCED OR METASTATIC TUMORS
Trial phase:
Phase
I
Study ID:
NCT04881045
Local study ID:
RG1121636
Summary:
This is a first-in-human, Phase 1, open label, multicenter, multiple dose, dose escalation and dose expansion study intended to evaluate the safety, pharmacokinetic, pharmacodynamic and potential clinical benefit of PF-07257876, a CD47-PD-L1 bispecific antibody, in participants with selected advanced or metastatic tumors for whom no standard therapy is available. The study contains 2 parts, single agent Dose Escalation (Part 1) to determine the recommended dose of PF-07257876, followed by Dose Expansion (Part 2) in selected tumor types at the recommended dose.
Trial keywords:
Ovarian Cancer, Lung Carcinoma, Non-Small-Cell (NSCLC), Carcinoma, Squamous Cell, Neoplasms, Squamous Cell
Enrollment status:
Recruiting
Trial eligibility
** For Eligibility information, please click on the "Look up trial at NIH" link above **
Other eligibility criteria may apply.
Other eligibility criteria may apply.
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