An advanced form of radiation treatment, proton therapy can be calibrated with great precision to selectively kill cancer cells. The clinical benefits proton therapy offers over standard X-ray treatment for certain types of cancer are becoming increasingly well known. The accuracy of the delivery of proton radiation, for example, reduces damage to the healthy tissues and organs surrounding tumors. Other benefits include fewer side effects, including a decreased risk of developing secondary tumors (cancers that result from radiation treatment).
The SCCA Proton Therapy Center, located on the University of Washington Medical Center – Northwest campus, benefits patients in the Pacific Northwest who no longer need to travel to other parts of the country for a multi-week course of treatment. Because of the significant investment required in building and operating a proton therapy facility, this center is the only proton facility in a seven-state region.
Who can benefit from proton therapy?
Virtually all doctors who specialize in radiation therapy agree that the most critical use of this technology is in treating children. Children are more prone to secondary cancers than adults. The risk of secondary cancers is correlated with the amount of irradiated tissue; since proton therapy is more efficient in sparing normal tissue, it reduces the likelihood of these follow-on cancers occurring in later years. Studies show that using proton therapy to treat certain pediatric tumors provides excellent results.
In adults, proton therapy can also be beneficial in treating a broad range of cancerous — and some non-cancerous — tumors, including those of the brain, central nervous system, gastrointestinal tract, head and neck, lung and prostate, as well as sarcomas. The advantages of proton therapy over standard X-ray treatment are similar to those experienced by pediatric patients. Proton therapy is most commonly recommended for adult patients in treating anatomically complex tumors where avoiding damage to healthy adjoining tissue—particularly critical organs and structures — is imperative.
Since proton therapy was approved by the U.S. Food and Drug Administration to treat patients in 1988, the medical community has continued to conduct research on the use of protons in treating different types of cancer through clinical trials. Over the years, many patients have volunteered to take part in these clinical trials to help find improvements in fighting cancer with proton therapy.
Our physicians view the SCCA Proton Therapy Center as a tremendous opportunity to take the lead in active clinical investigations that will help define the role of proton therapy in future cancer treatment. Ongoing studies conducted by Seattle Cancer Care Alliance (SCCA) physicians will help chart a clear course for the use of proton radiation in achieving the best possible outcomes in treating cancer.
What to expect
If your oncology team recommends proton therapy, you’ll need to plan ahead for a course of treatment that will typically cover a period of four to eight weeks. Your planning should include considering where you’ll live during this time — if you live beyond a commuting distance to Seattle.
SCCA makes available short-term rental housing for patients. For more information on housing opportunities in Seattle, visit our housing options section.
Initial consultation and treatment planning
Prior to treatment, you’ll meet with your radiation oncologist and nurse to discuss your treatment plan. You’ll also meet other members of your care team at the SCCA Proton Therapy Center, who will work with you throughout your entire course of treatment—and remain involved during follow-up care. We urge you to use this time to get answers to any remaining questions you may have about proton therapy.
Before treatment begins, you’ll also be asked to come to the SCCA Proton Therapy Center for a computed tomography simulation (CT) scan. This imaging will be used by your medical team to precisely map out your tumor and customize your treatment plan.
Your radiation oncologist will determine the length of treatment and exact dosage appropriate for your specific needs. Once your personal treatment plan is completed, you’ll be contacted by a radiation therapist on your care team to schedule your appointments for proton therapy. Most patients are scheduled to receive therapy five days a week, excluding weekends and holidays, for a period of four to eight weeks.
Proton therapy FAQs
All radiation therapies, including protons and X-rays, destroy cancer cells by damaging their DNA. When protons reach the nucleus (or center) of cancer cells, they transfer energy to the cells’ electrons causing a series of interactions, or ionizing events, that damage the DNA. Cancer cells whose DNA is damaged beyond repair can no longer divide—and they ultimately die. These cells are then broken down and eliminated by the body’s natural processes.
Because they are heavy particles, protons can be easily manipulated—energized to specific velocities. Doctors determine the specific velocities for each patient; this will determine how deeply in the body the protons will deposit their maximum energy and cause the most damage to the targeted tumor cells.
As the protons move through the body, they interact with electrons and release energy, all the while slowing down. The point where the highest energy is pinpointed and released in the tumor is called the “Bragg peak.” Virtually all of the remaining protons are absorbed at this point; the healthy tissues beyond receive minimal radiation. In addition, the relatively large mass of protons means that there is very little side scatter in adjoining healthy tissue.
On their way to the tumor, however, protons do deposit radiation to healthy tissue, although (in contrast with X-rays) in a lower dosage than is received by the targeted tumor cells.
In many cases, yes. Cancer treatment frequently involves more than one approach. For example, proton therapy can be used in combination with chemotherapy, as a follow-on treatment to surgery, and/or in combination with standard X-ray radiation treatment. If your cancer can be treated most effectively with a combination of therapies, your doctor will discuss this with you.
The process of receiving proton therapy is sensation-free. During your actual treatment, you will not feel or see the proton beam. Most patients experience few side effects from proton therapy—either during or after treatment. For those who do report side effects, these are typically slight and occur after a number of treatments. Depending on the site of your tumor, possible side effects may include skin irritation in the direct path of the proton radiation, fatigue, and hair loss around the area being treated.
The side effects reported by proton therapy patients are, in general, less severe than the side effects that can result from standard X-ray radiation therapy, primarily because less healthy tissue is exposed to radiation in proton therapy. Most patients tolerate proton radiation treatments extremely well and are able to continue to work, exercise, and follow their daily routine relatively normally during their course of treatment.
Proton therapy is not experimental. It has been used to treat patients since the mid-1950s and was approved in 1988 by the U.S. Food and Drug Administration. Medicare and Medicaid began covering the procedure in 2000. To date, more than 100,000 people have received proton therapy at centers in Europe, Asia, and the United States.
Yes, the medical community continues to conduct research studies on proton therapy. SCCA and other academic medical centers are supporting many ongoing clinical trials to expand our knowledge of the most beneficial applications of proton therapy in treating cancer.
Proton therapy is not the right approach for all types of cancers or all patients. It is most effective in treating solid tumors that are well defined and localized — those that have not spread to other areas of the body. If the tumor has spread (metastasized), proton therapy may still be an option, depending on the extent of the metastasis and other factors.
Virtually all doctors who specialize in radiation therapy agree that the most promising use of this proton therapy is in treating children. Children are more prone to secondary cancers than adults. The risk of secondary cancers is correlated with the amount of irradiated tissue, and since proton therapy is more efficient in sparing normal tissue, it reduces the likelihood of these follow-on cancers occurring in later years.
Damage to healthy tissues from radiation therapy can also cause growth abnormalities, reductions in IQ, and other complications in children. Thus, the advantages of avoiding standard X-ray therapy are compelling—and studies show that using proton therapy to treat pediatric tumors provides excellent results.
Tumors in children that can benefit most from proton therapy are those of the brain, head, neck, spinal cord, heart, and lungs.
In many cases, yes. Proton therapy can be used to treat recurrent cancers that are untreatable by standard X-ray radiation. Patients should discuss proton therapy with their radiation oncologist to determine if it can be beneficial in their particular case. Proton therapy can also be an option for patients who have already had a course of standard X-ray radiation and are unable to receive more.
X-rays and protons can be equally effective in destroying cancer tumors. The difference is that X-ray treatments damage more healthy tissue in the process, as their delivery is less precise. X-rays release much of their energy shortly after penetrating the skin, damaging healthy tissue and organs on their way to the tumor and again as they pass through the body beyond the tumor.
Protons can be precisely calibrated and directed to release most of their energy at the site of the tumor. Thus, higher doses of radiation typically can be delivered more safely with proton therapy as they pose much less exposure to healthy tissue.