Stephen Douglas Smith, MD

Physician
Fred Hutch
Associate Professor, Division of Medical Oncology
University of Washington School of Medicine
Associate Professor, Clinical Research Division
Fred Hutch
Specialty:
Medical Oncology
“Every patient deserves thorough, up-to-date information, compassion and access to cutting-edge therapies through clinical trials.”
— Dr. Smith
Why did you decide to become an oncologist?

I settled on becoming a doctor while studying biology as an undergraduate. I was interested in applying science to directly help people, and I wanted to be part of the revolution in medicine related to advances in molecular biology. Oncology interests me because, more than any other field of medicine, it combines the essential skills of doctoring, the use of rapidly improving treatments and the opportunity to forge deep bonds with patients.

Oncologist A physician who has special training in diagnosing and treating cancer. Some oncologists specialize in a particular type of cancer treatment, such as treating cancer with radiation. A physician who has special training in diagnosing and treating cancer. Some oncologists specialize in a particular type of cancer treatment. For example, a radiation oncologist specializes in treating cancer with radiation.
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What is your approach to care?

Rapid advancements have turned hematologic cancers into very treatable conditions, but these diseases still require individualized care. My approach is to design a treatment plan tailored to your specific situation, which includes offering you the newest, most promising therapies. I also believe it’s essential to provide you with all the information you need to make the best treatment decisions for yourself. Sharing thorough, up-to-date information to support your decision-making is at the core of our relationship.

Treatment plan A detailed plan with information about a patient’s disease, the goal of treatment, the treatment options for the disease and the possible side effects and expected length of treatment. A detailed plan with information about a patient’s disease, the goal of treatment, the treatment options for the disease and the possible side effects and expected length of treatment. A treatment plan may also include information about how much the treatment is likely to cost and about regular follow-up care after treatment ends.

Provider background

Specialty: Medical Oncology

Area of clinical practice

Hematologic malignancies

Lymphoma and blood disorders

I am a medical oncologist who cares for patients with lymphoma and other blood disorders and a member of the American Society of Hematology and the American Society of Clinical Oncology. My research focuses on developing and testing new drugs for hematologic malignancies. I’m especially interested in how the immune system works and how we can modify it when it goes awry — in particular, how we can use immunotherapies to treat blood-related cancers like lymphomas. I’m hopeful that, through research, we will find better ways to eradicate these diseases. And, for those diseases that we can’t cure, we should be able to control them with well-tolerated medicines over a person’s normal lifespan.

Immunotherapy A type of therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection and other diseases. A therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection and other diseases. Some immunotherapies only target certain cells of the immune system. Others affect the immune system in a general way. Types of immunotherapy include cytokines, vaccines, bacillus Calmette-Guerin (BCG) and some monoclonal antibodies. Lymphoma Cancer that begins in the cells of the immune system. There are two basic categories of lymphomas: Hodgkin lymphoma and non-Hodgkin lymphomas. Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer. Medical oncologist A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A medical oncologist is often the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists.

Diseases treated

Education, experience and certifications
Undergraduate Degree
Stanford University
Medical Degree
Keck School of Medicine of USC
Residency
Los Angeles County/USC Medical Center, Internal Medicine
Fellowship
Cleveland Clinic Foundation Program, Hematology and Oncology
Board Certification
Hematology, 2008, 2018, American Board of Internal Medicine

Stories

SCCA reaches milestone in Mantle Cell Lymphoma
SCCA reaches milestone in Mantle Cell Lymphoma

Seattle Cancer Care Alliance (SCCA) treats more MCL patients than almost any other center in the Pacific Northwest region and offers one of the nation’s most robust portfolios of standard treatments and clinical trials, in partnership with Fred Hutchinson Cancer Research Center and University of Washington Medical Center (UWMC)

Research

Clinical trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch doctors. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your doctor can decide if a study is right for you.

Study ID:
NCT04669171
A Novel Vaccine (EO2463) as Monotherapy and in Combination, for Treatment of Patients With Indolent Non-Hodgkin Lymphoma (SIDNEY)
Complete title
A global multicenter phase 1/2 trial of EO2463, a novel microbial-derived peptide therapeutic vaccine, as monotherapy, and in combination with lenalidomide and rituximab, for treatment of patients with indolent Non-Hodgkin's Lymphoma
Study ID:
NCT05011058
An Open-Label, Phase 2 Trial of Nanatinostat in Combination With Valganciclovir in Patients With Epstein-Barr Virus-Positive (EBV+) Relapsed/Refractory Lymphomas (NAVAL-1)
Complete title
An Open-Label, Phase 2 Trial of Nanatinostat in Combination with Valganciclovir in Patients with Epstein-Barr Virus-Positive (EBV+) Relapsed/Refractory Lymphomas (NAVAL-1)
Study ID:
NCT05225584
Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors
Complete title
A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Intravenously Administered KT-333 in Adult Patients with Relapsed or Refractory Lymphomas, Large Granular Lymphocytic Leukemia, and Solid Tumors

Publications

Many of our Fred Hutch doctors conduct ongoing research to improve standards of patient care. Their work is evaluated by other doctors and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch provider has written.

Press

Our providers are often asked to give their medical expertise for press and news publications. Read articles by or about this Fred Hutch provider.

Your care team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes doctors, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like nutritionists, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.
Registered nurse (RN)
Registered nurse (RN)
Your nurse manages your care alongside your doctor and assists with care procedures and treatments.
Patient care coordinator
Patient care coordinator
Your patient care coordinator works closely with you and your doctor and serves as your scheduler.

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

For providers