Mazyar Shadman, MD, MPH

Physician
Seattle Cancer Care Alliance
Associate Professor, Division of Medical Oncology
University of Washington School of Medicine
Associate Professor, Clinical Research Division
Fred Hutchinson Cancer Research Center
Specialty:
Medical Oncology
“Your positive attitude and willingness to fight have always inspired me.”
— Dr. Shadman
What do you enjoy about being an academic physician?

Every day, I get to integrate science with the art of human interaction. Seeing patients benefit from medical advances, and being active in pushing the science forward, is extremely rewarding. It’s an exciting time for both cancer care and research. We now have access to a variety of novel therapies that enable us to target cancer cells more specifically without causing major side effects. In my field, we’re always looking for a “cure,” but in the meantime, I’m hopeful that we can relegate cancer to a chronic disease and help patients maintain their desired quality of life.

Side effects A problem that occurs when treatment affects healthy tissues or organs. Some side effects of cancer treatment are nausea, vomiting, fatigue, pain, decreased blood cell counts, hair loss and mouth sores.
Shadman
What is your role in cancer treatment?

A diagnosis of cancer kicks off a torrent of life changes, and in the middle of all this disruption are many important decisions to make about your care. My role is to help you thoroughly understand and weigh your options. At SCCA, you have access to a variety of standard and experimental treatments, from chemotherapy to more novel, targeted approaches that may have fewer side effects. We’ll discuss each option in detail — the potential benefits, the risks and the overall impact on your life and family — so that you can make the best choices for your unique situation.

Chemotherapy Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It may be given alone or with other treatments. Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemotherapy may be given by mouth, injection, infusion or on the skin, depending on the type and stage of the cancer being treated. It may be given alone or with other treatments, such as surgery, radiation therapy or biologic therapy. Side effects A problem that occurs when treatment affects healthy tissues or organs. Some side effects of cancer treatment are nausea, vomiting, fatigue, pain, decreased blood cell counts, hair loss and mouth sores.

Provider background

Specialty: Medical Oncology

Area of clinical practice

Adult Blood and Marrow Transplantation, Cellular Immunotherapy, Hematologic Malignancies

Lymphomas

I am a medical oncologist and stem-cell transplant expert who specializes in treating patients with lymphomas and other blood disorders. My clinical trial work focuses on testing novel agents for the treatment of leukemia and lymphoma, with a particular focus on chronic lymphocytic leukemia (CLL). I also study the clinical outcomes of patients who have already been treated. My goal is to identify patient- or disease-specific characteristics that can help us understand the behavior of a disease and predict its responsiveness to different treatments. One particular area of interest is the epidemiology of hematologic neoplasms (abnormal growth in blood-forming tissue). In 2013, I co-authored a study that found a correlation between certain types of allergies and blood cancers.

Clinical trial A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis or treatment of a disease. Immunotherapy A type of therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection and other diseases. A therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection and other diseases. Some immunotherapies only target certain cells of the immune system. Others affect the immune system in a general way. Types of immunotherapy include cytokines, vaccines, bacillus Calmette-Guerin (BCG) and some monoclonal antibodies. Lymphoma Cancer that begins in the cells of the immune system. There are two basic categories of lymphomas: Hodgkin lymphoma and non-Hodgkin lymphomas. Cancer that begins in cells of the immune system. There are two basic categories of lymphomas. One is Hodgkin lymphoma, which is marked by the presence of a type of cell called the Reed-Sternberg cell. The other category is non-Hodgkin lymphomas, which includes a large, diverse group of cancers of immune system cells. Non-Hodgkin lymphomas can be further divided into cancers that have an indolent (slow-growing) course and those that have an aggressive (fast-growing) course. These subtypes behave and respond to treatment differently. Both Hodgkin and non-Hodgkin lymphomas can occur in children and adults, and prognosis and treatment depend on the stage and the type of cancer. Medical oncologist A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A medical oncologist is often the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists.

Diseases treated

Education, experience and certifications
Medical Degree
Tehran University of Medical Sciences
Residency
Cleveland Clinic Foundation, Internal Medicine
Fellowship
University of Washington, Hematology-Oncology
Board Certification
Medical Oncology, 2014; Hematology, 2014; Internal Medicine, 2011, American Board of Internal Medicine
Other
MPH, University of Washington
Languages
English
Persian

Stories

Understanding treatment options for standard- and high-risk CLL 
Understanding treatment options for standard- and high-risk CLL 

Current treatment options of chronic lymphocytic leukemia (CLL) go far beyond chemotherapy. Thanks to novel agents like ibrutinib, acalabrutinib and venetoclax, there are now chemotherapy-free treatment options that can potentially minimize treatment time and side effects for every patient with CLL.

Research

Clinical trials

We make promising new treatments available to you through studies called clinical trials led by SCCA doctors. Many of these trials at SCCA have led to FDA-approved treatments and have improved standards of care globally. Together, you and your doctor can decide if a study is right for you.

Study ID:
NCT04978779
A Study to Evaluate VIP152 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia or Richter Syndrome
Complete title
An Open-Label, Multicenter Phase 1 Dose Escalation Study to Characterize Safety, Tolerability, Preliminary Antitumor Activity, Pharmacokinetics, and Maximum Tolerated Dose of VIP152 in Subjects with Relapsed/Refractory Chronic Lymphocytic Leukemia or Richter Syndrome
Study ID:
NCT05360238
Study to Assess Safety, Tolerability and Efficacy of MB-106 in Patients With Relapsed or Refractory B-Cell NHL or CLL
Complete title
A Phase 1/2, Open Label, Multicenter Study to Assess the Safety, Tolerability and Efficacy of MB-106 in Patients with Relapsed or Refractory CD20+ B-Cell Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia
Study ID:
NCT04269902
Testing the Effects of Early Treatment With Venetoclax and Obinutuzumab Versus Delayed Treatment With Venetoclax and Obinutuzumab for Newly Diagnosed Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Who Do Not Have Symptoms, the EVOLVE CLL/SLL Study
Complete title
Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed Therapy with Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients with Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study

Publications

Many of our SCCA physicians conduct ongoing research to improve standards of patient care. Their work is evaluated by other physicians and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this SCCA provider has written.

Press

SCCA providers are often asked to give their medical expertise for press and news publications. Read articles by or about this SCCA provider.

Your care team

At SCCA, you receive care from a team of providers with extensive experience in your disease. Your team includes doctors, a team coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like nutritionists, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.
Registered nurse (RN)
Registered nurse (RN)
Your nurse manages your care alongside your physician and assists with care procedures and treatments.
Patient care coordinator
Patient care coordinator
Your patient care coordinator works closely with you and your physician and serves as your scheduler.

Insurance

SCCA accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

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