Top Doctor Top Doctor
The Top Doctor award is a peer-nominated award for providers who give exceptional care.

John A. Thompson, MD

Medical Director, Phase I Clinical Trials Program
Fred Hutch
Professor, Division of Oncology
University of Washington School of Medicine
Professor, Clinical Research Division
Fred Hutch
Specialty:
Medical Oncology
“Our research creates hope and possibility; I’m thrilled when our work makes an impact on your treatment.”
— Dr. Thompson
What excites you about your job?

It was during my internal medicine residency that I first became interested in oncology. I was inspired by both the science of cancer and the relational side of this specialty — the connections you form with patients and families. At Fred Hutch, I’m able to have dual careers: I get to experience the thrill of discovering better approaches to treating melanoma and kidney cancer while also witnessing firsthand the significance of this progress. Our research creates hope and possibility; I’m thrilled when our work makes an impact on your treatment.  

Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines.
Dr-john-thompson-secondary.jpg
How do you like to work with patients?

My goal is to establish a clear diagnosis, share with you the natural history of melanoma or kidney cancer as it affects you and develop a treatment plan that is based on good science and tailored to your needs. I know that learning  about your illness can be daunting. Sorting through all the available cancer information takes patience and time. One of my roles as an oncology specialist is to help you and your family sift through the data and find what’s useful to you. Patients often feel relieved when they can narrow down their information base and spend more time and energy taking care of themselves.  

Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Treatment plan A detailed plan with information about a patient’s disease, the goal of treatment, the treatment options for the disease and the possible side effects and expected length of treatment. A detailed plan with information about a patient’s disease, the goal of treatment, the treatment options for the disease and the possible side effects and expected length of treatment. A treatment plan may also include information about how much the treatment is likely to cost and about regular follow-up care after treatment ends.

Provider background

Specialty: Medical Oncology

Area of clinical practice

Kidney cancer, skin cancers

Melanoma, kidney cancer

I am a board-certified medical oncologist who specializes in the treatment of kidney cancer and melanoma. At Fred Hutch, I serve as the co-director of the melanoma clinic and the medical director of the Phase 1 Clinical Trials Program. Researchers in this program collaborate with local biotech and pharmaceutical companies to develop novel therapies for patients with solid tumor cancers. Phase 1 clinical trials can be a good option when conventional cancer treatments have stopped working.  

My clinical research focuses on exploring novel therapies for kidney cancer and melanoma, including blood stem cell transplants and immunotherapy. I was part of the team at Fred Hutch that reported the first successful use of a patient’s own T cells (a type of infection-fighting immune cell) as the sole therapy for putting an advanced solid-tumor cancer into long-term remission without radiation or chemotherapy. In addition to caring for patients and leading research, I’m active on many boards and committees that represent patients with kidney cancer and melanoma.

Chemotherapy Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It may be given alone or with other treatments. Treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemotherapy may be given by mouth, injection, infusion or on the skin, depending on the type and stage of the cancer being treated. It may be given alone or with other treatments, such as surgery, radiation therapy or biologic therapy. Immunotherapy A type of therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection and other diseases. A therapy that uses substances to stimulate or suppress the immune system to help the body fight cancer, infection and other diseases. Some immunotherapies only target certain cells of the immune system. Others affect the immune system in a general way. Types of immunotherapy include cytokines, vaccines, bacillus Calmette-Guerin (BCG) and some monoclonal antibodies. Medical oncologist A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A medical oncologist is often the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists. Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Remission A decrease in, or disappearance of, signs and symptoms of cancer. A decrease in, or disappearance of, signs and symptoms of cancer. In partial remission, some (but not all) signs and symptoms of cancer have disappeared. In complete remission, all signs and symptoms of cancer have disappeared, although cancer still may be in the body. Stem cell A cell from which other types of cells develop. For example, blood cells develop from blood-forming stem cells. T cell A type of white blood cell. T cells are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. A type of white blood cell. T cells are part of the immune system and develop from stem cells in the bone marrow. They help protect the body from infection and may help fight cancer. Also called T lymphocyte and thymocyte.
Education, experience and certifications
Undergraduate Degree
Davidson College
Medical Degree
University of Alabama, Birmingham
Residency
University of Washington School of Medicine, Internal Medicine
Fellowship
University of Washington School of Medicine, Internal Medicine
Board Certification
Medical Oncology, 1985, American Board of Internal Medicine; Internal Medicine, 1982, American Board of Internal Medicine
Other
Internship, University of Washington School of Medicine
Languages
English
French
Awards
Seattle Magazine's 2018 Top Doctors Award

Dr. Thompson has been recognized as a Top Doctor in this peer-nominated award multiple years in a row.

Stories

Brent Hall
Brent Hall

Brent Hall lives his life at full speed. As a professional hydroplane driver, Brent races boats at over 150 mph, achieving a dream he had as a boy growing up on Mercer Island. He was a rookie driver later in life at 36, and has earned national rankings in several different classes of hydroplanes. Brent is focused on going fast on the water — but not too long ago, he had to slow things down in order to focus on cancer treatment.

Research

Clinical trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch doctors. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your doctor can decide if a study is right for you.

Study ID:
NCT04585750
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a p53 Y220C Mutation
Complete title
A Phase 1/2 Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of PC14586 in Patients with Advanced Solid Tumors Harboring a p53 Y220C Mutation
Study ID:
NCT04152018
Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.
Complete title
A PHASE 1 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF ESCALATING DOSES OF PF-06940434 IN PATIENTS WITH ADVANCED OR METASTATIC SOLID TUMORS

Publications

Many of our Fred Hutch doctors conduct ongoing research to improve standards of patient care. Their work is evaluated by other doctors and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch provider has written.

Your care team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes doctors, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like nutritionists, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.
Registered nurse (RN)
Registered nurse (RN)
Your nurse manages your care alongside your doctor and assists with care procedures and treatments.
Patient care coordinator
Patient care coordinator
Your patient care coordinator works closely with you and your doctor and serves as your scheduler.

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

For providers