Heather H. Cheng, MD, PhD

Director, Prostate Cancer Genetics Clinic
Fred Hutch
Associate Professor, Division of Medical Oncology
University of Washington School of Medicine
Associate Professor, Clinical Research Division
Fred Hutch
Specialty:
Medical Oncology
“I consider it a privilege and an important responsibility to work together with you to design the best treatment plan for your life as a whole person, not just as a patient.”
— Dr. Cheng
Have you had a personal experience with cancer, and what did it mean for you?

I didn’t set out to be a prostate cancer specialist, but this disease came very close to home when three members of my immediate family were affected by — and two ultimately died of — prostate cancer during my training. My father-in-law had metastatic prostate cancer for 16 years and maintained a high quality of life for most of that time. My grandfather also had metastatic prostate cancer and lived to the age of 96. There was a point when he had the option to participate in clinical trials, and he made the choice to forgo more treatment. His decision informs how I think about not just my excitement for new clinical trials as a physician and researcher, but also about the value of meeting each patient where they are, understanding their priorities and giving them access to the best treatment that makes sense for them.

Metastatic A metastatic cancer is a cancer that has spread to other areas of the body by way of the lymph system or bloodstream.
Cheng-secondary.jpg
What do you think patients appreciate most about the way you care for them?

I strive to offer information, guidance and support with the hope of making the path forward less frightening. Thanks to new scientific developments, clinical trials and treatments, oncology is always evolving, making it possible to instill hope into every day. Your quality of life is a high priority for me. I enjoy the teamwork involved in supporting you and your loved ones through treatment and survivorship.

Provider background

Specialty: Medical Oncology

Area of clinical practice

Genitourinary cancers, high risk prevention

Prostate cancer, prostate cancer genetics, bladder cancer, testicular cancer

I am the director of SCCA’s Prostate Cancer Genetics Clinic, which helps bring leading-edge genetic and genomic discoveries to patients. Among the first of its kind in the country, the clinic provides genetic counseling and testing, matches patients with precision oncology clinical trials and provides opportunities for cancer prevention and early detection. 

My research interests include studying the inherited genetics of prostate cancer risk, the relationship to cancer-specific mutations and the genomics of prostate cancer (how sets of genes within a tumor behave). A better understanding of the molecular genetics and genomics of an individual's prostate cancer may serve as precision biomarkers to help guide treatment decisions and clinical trial options, potentially avoiding unhelpful treatments. In some cases, this knowledge could be used to inform relatives about cancer risk and what can be done to reduce that risk.  

Clinical trial A type of research study that tests how well new medical approaches work in people. These studies test new methods of screening, prevention, diagnosis or treatment of a disease. Gene The functional and physical unit of heredity passed from parent to offspring. Genes are pieces of DNA, and most genes contain the information for making a specific protein.

Diseases treated

Education, experience and certifications
Undergraduate Degree
Princeton University
Medical Degree
University of Washington School of Medicine
Residency
University of Washington, Internal Medicine
Fellowship
University of Washington, Hematology-Oncology
Board Certification
Medical Oncology, 2013; Internal Medicine, 2010, American Board of Internal Medicine
Other
PhD, Molecular and Cellular Biology, Fred Hutchinson Cancer Research Center and University of Washington
Languages
English
Awards
Rising Stars in Healthcare, Becker’s Hospital Review, 2017
Kelsey Dickson-PCF Young Investigator, Prostate Cancer Foundation, 2015
Molecular Markers in Cancer Merit Award, Conquer Cancer Foundation of ASCO, 2012

Stories

Free germline genetic testing now available for all men with prostate cancer through the PROMISE registry
Free germline genetic testing now available for all men with prostate cancer through the PROMISE registry

Seattle Cancer Care Alliance (SCCA) is recruiting patients with prostate cancer to participate in a new registry called PROMISE — Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness. The PROMISE registry will help researchers learn more about how germline mutations affect prostate cancer outcomes.

Understanding the genetic link to prostate cancer helps James DeLong finetune treatment and protect his family
Understanding the genetic link to prostate cancer helps James DeLong finetune treatment and protect his family

As a lifelong educator, James DeLong believes in the power of research. So when he turned 50, he decided to sign up for a prostate cancer research study enrolling healthy men. The study involved an initial rectal exam plus an annual blood draw and questionnaire. 

Research

Clinical trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch doctors. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your doctor can decide if a study is right for you.

Study ID:
NCT02266745
A Phase 1, Open-Label, Dose-Escalation Study Evaluating the Safety, Pharmacokinetics, and Clinical Effects of Intravenously Administered PT-112 Injection in Subjects With Advanced Solid Tumors and Subsequent Dose Expansion Cohorts
Complete title
A Phase 1, Open-Label, Study Evaluating the Safety, Pharmacokinetics, and Clinical Effects of Intravenously Administered PT-112 Injection in Patients with Advanced Solid Tumors and Subsequent Expansion Cohorts
Study ID:
NCT04497844
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) (AMPLITUDE)
Complete title
A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants with Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
Study ID:
NCT04995198
Prostate Cancer Registry of Outcomes and Germline Mutations (PROMISE)
Complete title

Publications

Many of our Fred Hutch doctors conduct ongoing research to improve standards of patient care. Their work is evaluated by other doctors and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch provider has written.

Press

Our providers are often asked to give their medical expertise for press and news publications. Read articles by or about this Fred Hutch provider.

Your care team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes doctors, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like nutritionists, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.
Registered nurse (RN)
Registered nurse (RN)
Your nurse manages your care alongside your doctor and assists with care procedures and treatments.
Patient care coordinator
Patient care coordinator
Your patient care coordinator works closely with you and your doctor and serves as your scheduler.

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

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