Guang-Shing Cheng, MD
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One of the first patients I cared for at Fred Hutch was a women in her early twenties who’d had a blood stem cell transplant. The procedure cured her leukemia, but she went on to develop bronchiolitis obliterans syndrome (BOS). It’s a rare post-transplant complication that causes scar tissue to build up in the lungs, narrowing or blocking the airway. This condition kept her from going to nursing school, and although she beat the odds — living with BOS for 16 years — it eventually took her life. To go through an intense, lifesaving procedure like a transplant only to die of a lung disease is devastating. There’s a lot of potential benefit in figuring out how problems like BOS develop; my hope is that we can eliminate the incidence and severity of BOS and other cancer treatment-related lung problems. No one should have to live every day feeling like they can’t breathe.
Fred Hutch is unique in that it’s one of the few places in the country with a group like mine: pulmonologists who exclusively see patients with cancer. I work with people who have all types of disease, from melanoma to lung cancer to leukemias. A large part of my clinical practice is caring for patients experiencing respiratory problems after a blood stem cell transplant. It can be really frustrating for someone to bounce back from such a rigorous procedure and then all of a sudden have difficulty breathing. I think it’s important to share the facts — what we know and what we don’t know — and offer hope. Many people live quite well for decades with some level of lung dysfunction, and we are starting to recognize post-transplant complications like BOS earlier and earlier. I collaborate closely with the Long-term Follow-up Program team, infectious disease experts, oncologists and other specialists to help address lung-related issues.
Provider background
Specialty: Pulmonology
High risk prevention
I am a pulmonary critical care specialist who treats patients with respiratory problems related to cancer or cancer treatment. At Fred Hutch, I serve as the medical director of the pulmonary outpatient consult service and I provide care through the Lung Cancer Early Detection and Prevention Clinic. I am also an attending physician in the intensive care unit at UW Medical Center-Montlake.
My research is focused on improving outcomes for patients who experience lung complications following a stem cell transplant. A primary area of interest is bronchiolitis obliterans syndrome (BOS); my goal is to improve the prevention and early detection of this disease. I am also involved in multicenter national trials testing new treatments for BOS and other transplant-related lung conditions. My publications include several scientific, peer-reviewed articles about BOS and book chapters about pulmonary disease.
Diseases treated
Testimonials
Research
Clinical trials
We make promising new treatments available to you through studies called clinical trials led by Fred Hutch doctors. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your doctor can decide if a study is right for you.
Publications
Many of our Fred Hutch doctors conduct ongoing research to improve standards of patient care. Their work is evaluated by other doctors and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch provider has written.
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