Top Doctor Top Doctor
The Top Doctor award is a peer-nominated award for providers who give exceptional care.

Evan Y. Yu, MD

Clinical Research Director, Genitourinary Medical Oncology
Fred Hutch
Section Head, Medical Oncology, Clinical Research Division
Fred Hutch
Professor, Medical Oncology
University of Washington School of Medicine
Assistant Fellowship Director
UW Medicine
Professor, Clinical Research Division
Fred Hutch
Medical Director, Clinical Research Support
Fred Hutchinson Cancer Research Consortium
Medical Oncology
“Scientific understanding and science-based treatments are important, but there’s so much more to treating cancer.”
— Dr. Yu
How do you combine being a scientist and physician?

I always had a scientific bent and wanted to be a physician. The summer after my first year of med school, I worked with a urologist and met men being treated for prostate cancer. The patients, who were grappling with their diagnosis and considering their options, inspired me to specialize in oncology. I felt deep respect and compassion for those undergoing cancer treatment, but that really deepened once my father developed bladder cancer. Before my father’s illness, I was very much a molecular scientist. But having someone close to me get cancer made me think about the disease more holistically, rather than only as a ball of abnormal cells or a sample in a tissue culture dish. Now, I find myself dedicated to strengthening the links between clinical care and lab research so that the prognosis for patients only gets better and better. Today, I try to meld the clinical care and the biology. I’m passionate about searching for the next wave of cancer treatments — targeted agents with greater cancer specificity and fewer side effects for you.

Prognosis A statement about the likely outcome of a disease in a patient. Side effects A problem that occurs when treatment affects healthy tissues or organs. Some side effects of cancer treatment are nausea, vomiting, fatigue, pain, decreased blood cell counts, hair loss and mouth sores.
What do you uniquely bring to patients?

I plant myself directly on the line between the laboratory and the clinic and engage both sides to develop a personalized approach to a selection of novel therapies. Your medical care needs to be built on a foundation of science and education, but I also bring an added dimension to my job by understanding biologic mechanisms of drug sensitivity and resistance. It’s really about working with you as a whole person, not just your cancer. I also recognize the importance of your relationship with your circle of loved ones. Oncology gives doctors a rare opportunity to connect deeply with families — from the outset of treatment through the course of the disease, sometimes over several years. I value the chance to get to know you and your family and will work intensively with you over time.

Provider background

Specialty: Medical Oncology

Area of clinical practice

Genitourinary cancers

Genitourinary cancers

I’m a medical oncologist who specializes in genitourinary oncology — treating patients with prostate, bladder and testicular cancers. Since 2004, I’ve been taking part in innovative cancer research here at Fred Hutch. I work as the director of our Prostate Cancer Clinical Research Group and am a member of the Institute for Prostate Cancer Research, a collaboration between Fred Hutchinson Cancer Center and UW Medicine. We strive to understand the causes of prostate cancer and its progression, develop new prevention strategies, devise innovative diagnostics and improve survival and quality of life.

One of my areas of research is focused on developing new imaging compounds for use in PET scans that are easier to use and more likely to detect cancers. My other research interests include cancer treatment-induced bone loss, bone metastases, bone biomarkers, molecular imaging of bone, novel therapeutics and new immunotherapeutic approaches.

Imaging In medicine, a process that makes pictures of areas inside the body. Imaging uses methods such as X-rays (high-energy radiation), ultrasound (high-energy sound waves) and radio waves. Medical oncologist A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A physician who has special training in diagnosing and treating cancer in adults using chemotherapy, hormonal therapy, biological therapy and targeted therapy. A medical oncologist is often the main health care provider for someone who has cancer. A medical oncologist also gives supportive care and may coordinate treatment given by other specialists. Progression In medicine, the course of a disease, such as cancer, as it becomes worse or spreads in the body.

Diseases treated

Education, experience and certifications
Medical Degree
University of Washington School of Medicine
Bringham and Women's Hospital, Internal Medicine
Dana-Farber Cancer Institute, Hematology-Oncology
Board Certification
Medical Oncology, 2003, 2013, American Board of Internal Medicine
Chinese (Mandarin)
Seattle Magazine's 2018 Top Doctors Award

Dr. Yu has been recognized as a Top Doctor in this peer-nominated award.

U.S. News and World Report “Top Doctor” 2011–present
Castle Connolly America’s Top Doctors 2011–present


Clinical trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch doctors. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your doctor can decide if a study is right for you.

Study ID:
A Study of Disitamab Vedotin Alone and With Pembrolizumab in Urothelial Cancer That Expresses HER2
Complete title
A Phase 2 Multi-Cohort, Open-Label, Multi-Center Clinical Study Evaluating the Efficacy and Safety of Disitamab Vedotin (RC48-ADC) Alone and in Combination with Pembrolizumab in Subjects with Locally-Advanced Unresectable or Metastatic Urothelial Carcinoma That Expresses HER2
Study ID:
Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations (SURF301)
Complete title
A Multicenter, Open-label Phase 1/2 Study of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors with Activating FGFR3 Gene Alterations (SURF-301)
Study ID:
Study of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (MK-3475-365/KEYNOTE-365)
Complete title
Phase Ib/II Trial of Pembrolizumab (MK-3475) Combination Therapies in Metastatic Castration-Resistant Prostate Cancer (mCRPC) (KEYNOTE-365)


Many of our Fred Hutch doctors conduct ongoing research to improve standards of patient care. Their work is evaluated by other doctors and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch provider has written.


Our providers are often asked to give their medical expertise for press and news publications. Read articles by or about this Fred Hutch provider.

Your care team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes doctors, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like nutritionists, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.
Registered nurse (RN)
Registered nurse (RN)
Your nurse manages your care alongside your doctor and assists with care procedures and treatments.
Patient care coordinator
Patient care coordinator
Your patient care coordinator works closely with you and your doctor and serves as your scheduler.


Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

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