Melanoma

Facts

Melanoma is the most serious form of skin cancer, compared to basal cell and squamous cell carcinoma. But most melanomas can be cured if they’re found and treated early, before they spread. So it’s important to learn the warning signs and how the disease is diagnosed.

If you’ve already been told you have melanoma, Fred Hutchinson Cancer Center offers comprehensive treatment from a team of experts who specialize in skin cancers.

Following the merger of long-time partners, Fred Hutchinson Cancer Research Center and Seattle Cancer Care Alliance, the organization was renamed to Fred Hutchinson Cancer Center. We are an independent, nonprofit organization that also serves as UW Medicine's cancer program. 

Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Sign In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. Some examples of signs are fever, swelling, skin rash, high blood pressure and high blood glucose.

What is melanoma?

Melanoma is cancer that begins in melanocytes, cells that make melanin, the pigment that determines your natural skin color.

Cancer cells do not respond like healthy cells to signals that regulate cell growth, division and death. They also don’t stop growing after they have reached normal boundaries. Instead they grow into a tumor, which may invade surrounding layers of tissue and spread to other organs.

Normally, melanocytes are at the bottom of your epidermis, the outer layer of your skin. Abnormal melanocytes that have turned into cancer may grow:

  • Up, forming a raised bump that you can see and feel
  • Down into the second layer of your skin, the dermis
  • Out along your skin

If melanoma cells enter your blood vessels or lymph vessels, they may spread to other parts of your body too.

Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines.

Symptoms

Melanoma skin cancer is much more serious than basal cell carcinoma and squamous cell carcinoma. It can spread quickly to other organs and causes the vast majority of skin cancer deaths in the United States. Usually melanomas develop in or around an existing mole.

Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines.
Signs and symptoms of melanoma

Signs and symptoms of melanoma vary depending on the exact type and may include:

  • A flat or slightly raised, discolored patch with irregular borders and possible areas of tan, brown, black, red, blue or white (superficial spreading melanoma)
  • A firm bump, often black but occasionally blue, gray, white, brown, tan, red or your usual skin tone (nodular melanoma)
  • A flat or slightly raised mottled tan, brown or dark brown discoloration (lentigo maligna)
  • A black or brown discoloration, usually under the nails, on the palms or on the soles of the feet (acral lentiginous melanoma) 
Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Sign In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. Some examples of signs are fever, swelling, skin rash, high blood pressure and high blood glucose. Symptom A physical or mental problem that a person experiences that may indicate a disease or condition. Symptoms cannot be seen and do not show up on medical tests. A physical or mental problem that a person experiences that may indicate a disease or condition. Symptoms cannot be seen and do not show up on medical tests. Some examples of symptoms are headache, fatigue, nausea and pain.

In addition to watching for skin lesions or other changes described above, read about symptoms of other forms of skin cancer, and see pictures.

Symptom A physical or mental problem that a person experiences that may indicate a disease or condition. Symptoms cannot be seen and do not show up on medical tests. A physical or mental problem that a person experiences that may indicate a disease or condition. Symptoms cannot be seen and do not show up on medical tests. Some examples of symptoms are headache, fatigue, nausea and pain.

Learn how to examine your skin and which general skin cancer warning signs to look for.

Sign In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. Some examples of signs are fever, swelling, skin rash, high blood pressure and high blood glucose.

Types

There are four basic types of melanoma.

Superficial spreading melanoma

Superficial spreading melanomaThis is the most common type of melanoma. It travels along the top layer of skin for a long time before going deeper. It can be found almost anywhere on the body but is more common on areas exposed to more ultraviolet (UV) light, from either the sun or an artificial source, like a tanning bed.


Appearance: The first sign is a flat or slightly raised, discolored patch with irregular borders. The color varies and might include areas of tan, brown, black, red, blue or white.

Superficial spreading melanoma

Nodular melanoma

Nodular melanomaThis type grows into the dermis more quickly than other types do.


Appearance: Looks and feels like a firm bump, often black but occasionally blue, gray, white, brown, tan, red or your usual skin tone.

Nodular melanoma

Lentigo maligna

Lentigo malignaThis type of melanoma stays close to the skin’s surface for a long time. It is more often found in older people on skin chronically exposed to and damaged by the sun. 

Appearance: Usually appears as a flat or mildly elevated mottled tan, brown or dark brown discoloration.

Lentigo maligna

Acral lentiginous melanoma

Acral lentiginous melanomaThis type spreads near the surface before growing deeper into the skin. It is not related to UV light and is usually found under the nails, on the palms or on the soles of the feet. Overall, this is the least common type of melanoma, but it’s the most common type in people with darker skin.


Appearance: A black or brown discoloration.

Acral lentiginous melanoma

 

Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Sign In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. Some examples of signs are fever, swelling, skin rash, high blood pressure and high blood glucose.

Diagnosing

If you have not been diagnosed with skin cancer but you are concerned about your moles or other pigmented lesions, you may want to make an appointment for an evaluation at the Dermatologic Clinic at UW Medical Center-Roosevelt, especially if you are at risk for melanoma

If you have an abnormal-looking growth on your skin that might be melanoma, your doctor will:

  • Review and ask about your medical history and family history.
  • Ask about your sun exposure, lifestyle, medicines and other risk factors. 
  • Ask about your symptoms, when the lesion first appeared and if it has changed in size or appearance. 
  • Perform a thorough physical exam and check the skin lesion, any other suspicious moles or marks and your lymph nodes. 
Lesion An area of abnormal tissue. A lesion may be benign (not cancer) or malignant (cancer). Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Symptom A physical or mental problem that a person experiences that may indicate a disease or condition. Symptoms cannot be seen and do not show up on medical tests. A physical or mental problem that a person experiences that may indicate a disease or condition. Symptoms cannot be seen and do not show up on medical tests. Some examples of symptoms are headache, fatigue, nausea and pain.
Melanoma biopsy

If your doctor is concerned that a lesion might be cancer, they may recommend a skin biopsy. This involves taking a sample of suspicious tissue so a pathologist can examine the cells under a microscope to look for cancer cells. 

Common types of skin biopsies include:

  • Shave biopsy — A sterile razor blade is used to shave off the lesion.  
  • Punch biopsy — An instrument called a punch is used to remove a circle of tissue from the lesion.
  • Excisional biopsy — A scalpel is used to remove the entire growth.
Biopsy The removal of a sample of tissue or fluid that is examined to see whether cancer is present. This may be done with a large needle or through surgical removal of tissue or fluids. Biopsy The removal of a sample of tissue or fluid that is examined to see whether cancer is present. This may be done with a large needle or through surgical removal of tissue or fluids. Lesion An area of abnormal tissue. A lesion may be benign (not cancer) or malignant (cancer). Pathologist A physician who has special training in identifying diseases by studying cells and tissues under a microscope.
Sentinel lymph node mapping and biopsy

If you’ve been diagnosed with melanoma and your care team is concerned that cancer cells might have spread, your doctor will want you to have a sentinel lymph node biopsy. In this procedure:

  • A tracer substance and a dye are injected near your tumor.
  • The substance flows through lymph ducts to the first lymph node or nodes where cancer cells are likely to spread (sentinel nodes). 
  • Your surgeon removes only the nodes where the substance appears. 
  • A pathologist checks the sentinel nodes for cancer. 
Biopsy The removal of a sample of tissue or fluid that is examined to see whether cancer is present. This may be done with a large needle or through surgical removal of tissue or fluids. Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Pathologist A physician who has special training in identifying diseases by studying cells and tissues under a microscope.
Imaging studies and lab tests

Your doctor might recommend other tests or scans to learn more about your condition, especially if your tumor is deep or cancer is in your lymph nodes. These may include a computed tomography (CT) scan, chest X-ray, positron emission tomography (PET) scan, magnetic resonance imaging (MRI) scan or bone scan and tissue, blood or urine tests.

Bone scan A procedure to check for abnormal areas or damage in the bones. A bone scan may be used to diagnose bone tumors or cancer that has spread to the bone. A procedure to check for abnormal areas or damage in the bones. A very small amount of radioactive material is injected into a vein and travels through the blood. The radioactive material collects in the bones and is detected by a scanner (a special camera that takes pictures of the inside of the body). A bone scan may be used to diagnose bone tumors or cancer that has spread to the bone. It may also be used to help diagnose fractures, bone infections or other bone problems. [removed comma] Chest X-ray A type of high-energy radiation that can go through the body and onto film, making pictures of areas inside the chest, which can be used to diagnose disease. An X-ray is a type of high-energy radiation that can go through the body and onto film, making pictures of areas inside the chest, which can be used to diagnose disease. Computed tomography A procedure that uses a computer linked to an X-ray machine to make a series of detailed pictures of areas inside the body. The pictures are used to create three-dimensional (3-D) views of tissues and organs. A procedure that uses a computer linked to an X-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create three-dimensional (3-D) views of tissues and organs. A dye may be injected into a vein or swallowed to help the tissues and organs show up more clearly. This scan may be used to help diagnose disease, plan treatment or find out how well treatment is working. Imaging In medicine, a process that makes pictures of areas inside the body. Imaging uses methods such as X-rays (high-energy radiation), ultrasound (high-energy sound waves) and radio waves.
Dr. David Byrd discusses imaging scans to assess melanoma

Stages

Staging is the process of finding out whether your cancer has spread and, if so, to what extent. This helps guide your treatment.

Melanoma is assigned a stage from I to IV, with I being the least advanced and IV being the most advanced.

  • In stages I and II, melanoma is only in the skin.
  • In stage III, nearby lymph nodes are involved.
  • Stage IV melanoma affects distant organs in other parts of the body.
Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Stage The extent of a cancer in the body. Staging is usually based on the size of the tumor, whether lymph nodes contain cancer and whether the cancer has spread from the original site to other parts of the body. Staging Performing exams and tests to learn the extent of the cancer within the body, especially whether the disease has spread from where it first formed to other parts of the body. Performing exams and tests to learn the extent of the cancer within the body, especially whether the disease has spread from where it first formed to other parts of the body. It is important to know the stage of the disease in order to plan the best treatment.

Risk factors

Everyone is at some risk for melanoma and other skin cancers, but certain factors increase your risk. The major risk factor by far is exposure to UV light, especially if you have fair skin.

People with darker skin are at lower risk because they have more melanin, which provides some protection. But people with any skin tone can get melanoma.

Read details about skin cancer risk factors, including ways that UV-exposure increases your risk.

    Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines.
    General skin cancer risk factors

    These factors relate to all three of the major skin cancers. If any apply to you, take precautions to protect yourself by limiting your sun exposure and using sunscreen.

    You are at increased risk for skin cancer if:

    • You have fair skin; blond, red or light brown hair; blue, green or grey eyes; or freckles. (People with darker skin are at lower risk because they have more of the pigment melanin, which provides some protection. But people with any skin tone can get skin cancer.) 
    • You had several blistering sunburns as a child or teen, or you burn before you tan.
    • You spend a lot of time outdoors for work or recreation.
    • You work indoors all week and then are exposed to sun on the weekends — while playing, gardening or washing the car without a shirt on, for example.
    • You live or vacation in tropical or subtropical climates and areas with year-round, bright sunlight.
    • You live, work or vacation at high altitudes. 
    • You have been treated for skin cancer in the past.
    • One or more of your first-degree relatives (a parent, sibling or child) had skin cancer. The more family members who have had skin cancer, the higher your risk.
    • You have xeroderma pigmentosum, a rare, inherited condition in which your body cannot repair DNA damage caused by ultraviolet light.
    • Your immune system is weakened, such as if you are taking medications for an organ transplant, have AIDS or cancer or are on immune-suppressant medicines.
    • You have used tanning beds, booths or sunlamps.
    • You take any medicines that may be harmful when you are out in sunlight or make you more prone to sun damage. (These include tetracycline, sulfa drugs and some other antibiotics; naproxen sodium, ibuprofen and some other nonsteroidal anti-inflammatory drugs; phenothiazines; tricyclic antidepressants; thiazide diuretics; sulfonylureas; and medicines that lower your immunity.) If you’re not sure, ask your doctor, nurse or pharmacist.
    • You are older. Risk of developing skin cancer increases with age. But young people can get skin cancer too, and children are extremely susceptible to sun damage.

    In addition, the following factors may affect your risk for melanoma specifically:

    • Family history of certain cancers — You are at increased risk if you have family members with a history of melanoma (especially if multiple relatives had it), pancreatic cancer, astrocytoma (a form of brain cancer), uveal melanoma (involving the eye) or mesothelioma.
    • Moles — A mole (nevus) is a benign (noncancerous) collection of pigment cells. There’s active scientific discussion of whether moles turn into cancer. Let your doctor know if a mole becomes itchy, and check your body regularly for changing moles or other possible warning signs of skin cancer.
    • Dysplastic (atypical) nevi — These moles develop from childhood on through adulthood and often run in families. Lifetime melanoma risk is higher in people with dysplastic nevi. 
    Benign Not cancer. Benign tumors may grow larger but do not spread to other parts of the body. Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines. Sign In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. In medicine, a sign is something found during a physical exam or from a laboratory test that shows that a person may have a condition or disease. Some examples of signs are fever, swelling, skin rash, high blood pressure and high blood glucose.

    How common is it?

    Overall, skin cancers are the most common cancers in the United States. But melanoma is less common than the other two major types, basal cell and squamous cell carcinoma.

    Each year about 91,000 people in the U.S. are diagnosed with melanoma of the skin, according to the American Cancer Society. By comparison, about 3.3 million are diagnosed with one or more basal cell or squamous cell carcinomas.

    Melanoma Cancer that begins in the melanocytes (cells that make the pigment melanin). It may begin in a mole (skin melanoma), but it can also begin in other pigmented tissues, such as the eye or the intestines.
    Melanoma facts and stats infographic
    Melanoma facts and stats infographic