Some lymphomas may not respond well to treatment. When a cancer returns after treatment it is called recurrent or relapsed. In general, cutaneous lymphomas come back in the skin. Additional treatments may be tried and may be effective for a time.
Treatments for mycosis fungoides and Sezary syndrome may help patients, sometimes for years, but they are rarely cured.
Patients with recurrent disease that is no longer responding to treatment may want to consider entering a clinical study.