Aplastic anemia

Treatment

Aplastic anemia can be mild, moderate, or severe.

Mild or moderate aplastic anemia is serious but usually doesn't require hospitalization and may be treated with

  • Blood transfusions and/or medications
  • Immunosuppressive drugs
  • Growth factors

Severe aplastic anemia, in which blood cell counts are extremely low, is life-threatening, and requires immediate hospitalization for treatment, which is usually a bone marrow transplant. Replacing diseased bone marrow with healthy bone marrow from a donor often successfully cures aplastic anemia.

Treatment types

Treatment looks different for different people depending on your diagnosis. We tailor your treatment plan to you. Learn more about the treatment types offered at SCCA. 

Blood transfusions

Having a blood transfusion refers to a patient receiving blood cells from a donor. Transfusions help insure that an anemic patient’s blood cell count stays at a safe level. Platelet transfusions reduce the risk of bleeding problems caused when platelet counts are too low. Red blood cell transfusions reduce symptoms of fatigues.

However, having too many blood transfusions means that iron from red blood cell transfusions can build up in the body and cause organ damage, or, the immune system may develop antibodies that attack the transfused cells.

Blood transfusions

Having a blood transfusion refers to a patient receiving blood cells from a donor.

Immune-suppressive medications

Because one possible cause of aplastic anemia is the immune system working against itself, one or more immunosuppressive drugs are often given until a stem cell transplant can be performed.

Immune-suppressive medications

Because one possible cause of aplastic anemia is the immune system working against itself, one or more immunosuppressive drugs are often given until a stem cell transplant can be performed.

Growth factors

Growth factors are drugs that help the body make more blood cells, which may be given to reduce the number or need for blood transfusions. Given after immunosuppressive therapy or bone marrow transplant, growth factors can help blood cell production or may be used in combination with immune-suppressing drugs to relieve the symptoms of aplastic anemia.

Having aplastic anemia weakens the immune system leaving a person susceptible to all kinds of infections. White blood cells, responsible for fighting off infections, cannot be effectively replaced with a transfusion, so antibiotics are often administered when fever or infection appears.

Growth factors

Growth factors are drugs that help the body make more blood cells, which may be given to reduce the number or need for blood transfusions.

Bone marrow transplantation

Fred Hutchinson Cancer Research Center physicians pioneered bone marrow transplants for aplastic anemia treatment. If bone marrow or stem cell transplantation is indicated, patients will be seen by Hutchinson Center doctors who are world leaders in stem cell and bone marrow transplantation. When patients have the opportunity to use a matched sibling’s stem cells or bone marrow, there is a 90 percent success rate.

Outcomes are best with matched siblings when patients are under 20 years of age and early after diagnosis, have had minimal prior (irradiated) transfusions, marrow is used as the stem cell source, and CY (cyclosporine) and ATG (methyprednisolone, cyclosporine, and granulocyte colony stimulating factor) are used as conditioning prior to transplant.

Bone marrow transplantation

Fred Hutchinson Cancer Research Center physicians pioneered bone marrow transplants for aplastic anemia treatment.