Phase 2 Study of Tucatinib vs Placebo in Combination With Capecitabine & Trastuzumab in Patients With Advanced HER2+ Breast Cancer (HER2CLIMB)
Phase 2 Randomized, Double-Blinded, Controlled Study of ONT-380 vs. Placebo in Combination with Capecitabine and Trastuzumab in Patients with Pretreated Unresectable Locally Advanced or Metastatic HER2+ Breast Carcinoma
Investigator
Trial Phase
Phase II
Study Number
NCT02614794
Local Study ID
20152617
Trial Contact Phone
800-804-8824 / 206-606-1024
Summary
The purpose of this study is to assess the effect of tucatinib vs. placebo in combination with capecitabine and trastuzumab on progression-free survival (PFS) per RECIST 1.1 based on independent central review.
Trial Eligibility
*For Eligibility information, look up the trial at NIH by clicking on the Study Number above.*
Other eligibility criteria may apply.
Trial Exclusions
Other exclusion criteria may apply.
Trial Keywords
Breast Cancer; Solid Tumors; HER2-Positive; Immunotherapy
See this trial at ClinicalTrials.gov

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