Medical oncologists have three tools to fight breast cancer -- chemotherapy, endocrine therapy and hormone therapy. With hormone therapy, there are two strategies to get rid of hormone receptors that help cancer grow. Dr. VK Gadi describes these strategies including blocking the enzyme that turns pre-estrogen to active estrogen with a drug called Tamoxifen. The most serious side effects from treatment with Tamoxifen are blood clots, which occur in 2-3% of women taking the drug. Dr. Gadi discusses early warning indicators for these risks, and tells how he minimizes serious side effects with drugs such as aromatase inhibitors. He shares study results supporting his treatment strategy and points out the benefits to anti-estrogen therapy.