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Smith Apisarnthanarax, MD

Dr. Apisarnthanarax is a radiation oncologist with expertise in gastrointestinal cancers and genitourinary tumors, including prostate cancer. He also specializes in proton therapy, stereotactic body radiation therapy, and liver cancer.

Patient Care Philosophy:

Being diagnosed with and treated for cancer is one of the most arduous journeys that any person will experience. Every patient and every cancer is different. As a radiation oncologist, my goal is to guide patients through this difficult time by providing the most compassionate, personalized care possible and making sure they have access to the latest, innovative clinical trials and state-of-art technology.

Dr. Apisarnthanarax's Resume


  • Associate Professor, Department of Radiation Oncology, University of Washington School of Medicine
  • Radiation Oncologist, University of Washington Medical Center
  • Radiation Oncologist, Seattle Cancer Care Alliance
  • Radiation Oncologist, SCCA Proton Therapy Center

Clinical Expertise

Gastrointestinal cancers, proton beam radiation therapy, stereotactic body radiation therapy (SBRT), intensity-modulated radiation therapy (IMRT), prostate cancer, liver cancer, pancreatic cancer


Dr. Apisarnthanarax's practice includes general radiation oncology with a focus in gastrointestinal cancers, including liver, esophagus, stomach, pancreas, rectal, and anal cancers.

His research interests include optimizing the treatment of liver cancers, integrating proton beam radiation therapy into the multidisciplinary care of care, and using novel functional imaging to personalize cancer care by decreasing normal tissue toxicity and assessing cancer treatment response.

Education And Training

  • Bachelor of Arts Degree: Brown University, 1994-1998
  • Medical Degree: Brown University Warren Alpert Medical School, 1998-2002 
  • Residency: Radiation Oncology, University of North Carolina, 2005-2009
  • Fellowship: Experimental Radiation Oncology, M.D. Anderson Cancer Center, 2003-2005 
  • Internship: Northwestern University - Evanston Hospital, Evanston, IL, 2002-2003

More Information

Visit PubMed for a full listing of Dr. Apisarnthanarax's journal articles.

Clinical Trials

Dr. Apisarnthanarax is the SCCA lead investigator for the following clinical trials:

Dr. Apisarnthanarax's Story

“Cancer is a disease that affects every aspect of one’s life: physically, mentally, and emotionally,” says Dr. Smith Apisarnthanarax. “In my mind, that is what medicine is about–treating the patient and their families as a whole.”

Dr. Apisarnthanarax’s research interests revolves around optimizing the delivery of radiation therapy for gastrointestinal cancers, specifically in liver cancers where there is much to be learned  about on how best to safely give potentially curative radiation doses to the liver and how to integrate them with other available treatments. 

“Proton beam radiation is a modality that has been relatively uncultivated in gastrointestinal cancers,” he says. “It aligns with my research interests. I am interested about how best to optimally use proton radiation for gastrointestinal cancers to decrease side effects and enhance cure rates. I am also interested in the use of novel functional imaging to optimize radiation treatment planning and to predict responses to cancer therapies.”

The future of cancer treatment is “truly personalized cancer medicine,” he says. “Where every patient receives individualized treatments that provide the best chance of cure while minimizing toxicity.”

Outside of work, Dr. Apisarnthanarax and his family enjoy being together. “We’re foodies and movie buffs,” he says. But they also enjoy spending time exploring the outdoors.