Severe Combined Immune Deficiency (SCID)

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Treatment Options

If your child’s doctor suspects that he/she may have SCID, they will initially use antibiotic, antifungal, and antiviral medications to treat any active infections that your child may have.  They will also start antibiotics and Intravenous Immune Globulin (IVIG) to try and protect your child from getting some of the infections that they are susceptible to.

Bone Marrow Transplantation

Medications and IVIG can temporarily keep SCID patients healthy but ultimately, almost all patients with SCID require bone marrow transplantation (BMT). BMT provides SCID patients with a functioning immune system that is capable of protecting them from infections. It is a cure for the disease and is highly effective in the majority of patients.

Enzyme Replacement Therapy

If your child happens to have the type of SCID caused by deficiency of the enzyme Adenosine Deaminase (ADA), they can be given enzyme replacement therapy which can allow their immune cells to recover and may provide long-term benefit.

Gene Therapy

A handful of patients with SCID have also undergone gene therapy to correct the genetic mutation in their immune cells.  While this has been very successful in some patients, others have developed serious complications from this treatment. At this point, gene therapy is still considered an investigational treatment option but further studies are underway to improve this approach. 

Our doctors are very experienced in the care of patients with SCID and are well versed in the use of these therapies.  Many of them are performing leading-edge research related to immune deficiency diseases and are considered to be national and international experts in this field.