Hyper-IgM Syndrome (HIGM)

Text Size A A

E-Mail to a Friend

secret  Click to Play Audio

WHO WE ARE — Seattle Cancer Care Alliance is a world-class cancer treatment center that unites doctors from Fred Hutch, UW Medicine and Seattle Children's. Learn More


Hyper-IgM syndrome (HIGM) is a disorder that can be passed on from parent to child (genetic). People with HIGM do not have enough of the most efficient infection-fighting antibodies. They usually have very low levels of both immunoglobulin A (IgA) and immunoglobulin G (IgG). This makes it hard for them to fight off infections and illness.

Children and teens with HIGM are treated at Seattle Children’s, a founding organization of Seattle Cancer Care Alliance (SCCA). Seattle Children’s has a long history of successfully caring for children and teens with this and other immune system disorders.

Pediatric Bone Marrow Transplant Experts

If your child’s condition requires a bone marrow transplant, you should know that the Fred Hutchinson Bone Marrow Transplant Program at SCCA is one of the world’s largest and most experienced centers for pediatric transplantation. Doctors at Fred Hutchinson Cancer Research Center, another SCCA founding organization, pioneered the use of bone marrow transplants as a treatment for blood diseases over 40 years ago. We have now performed over 14,000 transplants, more than any other institution in the world. Nearly 20 percent of these have been done in children. Ours is one of only 13 bone marrow transplant centers whose patients achieved higher-than-expected survival rates, according to a recent study of 168 centers nationwide.

Learn More

Find out why families choose SCCA for pediatric bone marrow transplant.

Read more on the Seattle Children’s website about:

Make an Appointment

Contact us to schedule an appointment or ask questions.

  • To talk with a pediatric transplant doctor, call (800) 804-8824.
  • To reach Immunology at Seattle Children’s, call (206) 987-7450.