Dyskeratosis Congenita (DKC)

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Overview

Dyskeratosis congenita (DKC) is an inherited disorder. Symptoms may include abnormal skin pigmentation, abnormal nail growth, and leukoplakia (white patches inside the mouth), but many patients can have DKC without any of these symptoms. Patients with DKC are predisposed to bone marrow failure, some cancers, and pulmonary problems. A registry was established in 1995 to study the clinical features of this disease.

Classical symptoms of rash, nail abnormalities, and leukoplakia typically begin to surface between the ages of five and ten years but these symptoms may be absent in many patients.  DKC has been diagnosed at all ages from infancy until well into adulthood.

Outstanding Care Team

The medical team at Seattle Children's, a parent organization of Seattle Cancer Care Alliance, has a long history of successfully caring for children and teens who have DKC. These renowned specialists work together to improve your child's quality of life and conquer this disease.

Medical therapy for bone marrow failure diseases is provided at Seattle Children's. If your child's health-care team determines that the best course of action is a bone marrow transplant, your child will receive this treatment through Seattle Cancer Care Alliance, ranked first in outcomes  in a four-year study by the National Marrow Donor Program (NMDP) that measured one-year survival rates of patients among 122 transplant centers in the United States.