Hyper-IgE syndrome

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WHO WE ARE — Seattle Cancer Care Alliance is a world-class cancer treatment center that unites doctors from Fred Hutchinson Cancer Research Center, UW Medicine and Seattle Children's. Learn More


Hyper-IgE Syndrome (HIES) is a disorder that can be passed on from parent to child (genetic). It causes cells in the immune system to react abnormally to infections. This makes it hard for people with HIES to fight off infections, especially in the lungs and skin.

The medical team at Seattle Children's, an SCCA parent organization, has a long history of successfully caring for children and teens who have leukemia. 

Cancer Care Success Rates

Read about Seattle Children's success rates for treating pediatric cancers.

If your child's condition requires a bone marrow transplant, you should know that the Fred Hutchinson Transplant program at SCCA was ranked first in outcomes in a four-year study by the National Marrow Donor Program (NMDP) that measured one-year survival rates of patients among 122 transplant centers in the United States. The Hutchinson Center pioneered the use of bone-marrow transplants as a treatment for blood diseases over 40 years ago. Since then thousands of patients with leukemia have come from around the world to receive bone-marrow transplants at SCCA. Bone marrow transplants have transformed leukemia and related cancers, once thought incurable, into highly treatable diseases with survival rates as high as 80 percent.