Bone Marrow Transplant
|Closed||Graft Versus Host Disease
Multiple Myeloma and Plasma Cell Neoplasm
Small Intestine Cancer
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer cell growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cell-killing substances to them. Giving rituximab before and after donor stem cell transplant may kill more hematologic cancer cells.
PURPOSE: This phase II trial is studying rituximab in treating patients undergoing stem cell transplant for B-cell cancer that has relapsed or not responded to treatment.
|Genders Eligible for Study:||Both|
|Accepts Healthy Volunteers:||No|
Diagnosis of CD20-expressing B-cell malignancy
- Any histologic type or grade for which nonmyeloablative allogeneic transplantation is considered an appropriate treatment option
- Relapsed or refractory disease
Concurrently enrolled on a nonmyeloablative allogeneic hematopoietic cell transplantation protocol treatment plan employing total body irradiation (TBI)-based conditioning of ≤ 4 Gy, with or without fludarabine
Studies may include, but are not limited to, the following:
- Receiving unmodified peripheral blood mononuclear cell graft products
- Must have appropriate related or unrelated donor available (no HLA-haploidentical donors)
- No protocols involving bone marrow allografts
- Not pregnant or nursing
- Fertile patients must use effective contraception during and for ≥ 12 months after completion of study treatment
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- Enrollment in protocol FHCRC-1726.00 takes priority over this study for patients with chemorefractory aggressive non-Hodgkin lymphoma
- Enrollment in protocol FHCRC-1711.00 or FHCRC-1840.00 takes priority over this study for patients with chronic lymphocytic leukemia
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
- Talk to your health care providers first before making decisions about your health care.
- Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.