|Closed||Sarcoma; Solid Tumors||Phase III||
This is an international, randomized, double-blind, placebo-controlled trial to evaluate the clinical efficacy of palifosfamide-tris administered with doxorubicin in combination, compared with doxorubicin administered with placebo in front-line patients diagnosed with metastatic soft tissue sarcoma (STS).
|Ages Eligible for Study:||18 Years and older|
|Genders Eligible for Study:||Both|
|Accepts Healthy Volunteers:||No|
To be eligible, each patient must meet EACH of the following criteria:
- Age ≥18 years.
- Documented soft tissue sarcoma
- Metastatic disease for which the patient has not received any prior treatment, and for whom treatment with doxorubicin is considered medically acceptable.
- ECOG Performance Status of 0, 1 or 2
- Adequate bone marrow and organ function based on the results of protocol- specified laboratory tests
- Male and female patients must agree to use a highly reliable method of birth control during study participation.
- Able to provide informed consent
To be eligible, each patient must meet NONE of the following criteria:
- Specific sarcoma histological subtypes including GIST and Ewing's sarcoma.
- Systemic therapy for the treatment of metastatic sarcoma, prior to or during the study. However, patients may have received neo-adjuvant/adjuvant Gemzar and Taxotere chemotherapy for their primary sarcoma, prior to the development of metastatic disease
- Any prior anthracycline use.
- Known allergy to any of the study drugs or their excipients.
- Any unstable or clinically significant concurrent medical condition that would, in the opinion of the investigator, jeopardize the safety of a patient and/or their compliance with the protocol, based on screening tests, physical examination and medical history (as specifically defined in the clinical protocol).
- Myocardial dysfunction defined as left ventricular ejection fraction (LVEF) <50%.
- Documented metastases to brain or meninges.
- Any malignancy other than sarcoma within the last 5 years prior to screening, with the exception of cervical carcinoma in situ, basal cell carcinoma, or superficial bladder tumors (Ta, Tis, or T1) that have been successfully and curatively treated with no evidence of recurrent or residual disease.
- Currently pregnant or nursing.
- Radiotherapy with curative intent within 4 weeks of first dose of study drug.
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
- Talk to your health care providers first before making decisions about your health care.
- Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.