Prostate Cancer Clinical Trials
Diagnostic Imaging Study With 99mTc-MIP-1404 (20121505)
A Phase 2 Assessment of the Diagnostic Accuracy of Tc-MIP-1404 Imaging in Men with High-Risk Prostate Cancer Scheduled for Radical Prostatectomy and Extended Pelvic Lymph Node Dissection Compared to Histopathology
|Closed||Rectal Cancer; Solid Tumors||Phase II||
The purpose of this adaptive trial is to compare the progression-free survival of participants with metastatic rectal carcinoma when treated with dalotuzumab + irinotecan therapy relative to participants treated with cetuximab + irinotecan.
Eligibility Criteria (must meet the following to participate in this study)
- Male aged 21 years or older.
- Ability to provide signed informed consent and willingness to comply with protocol requirements.
- Biopsy confirmed presence of adenocarcinoma of the prostate gland.
- At high-risk for metastatic disease by a stage of cT3, cT4, or a total nomogram score of greater than or equal to 130.
- Scheduled to undergo radical prostatectomy with extended pelvic lymph node dissection.
- Agree to use an acceptable form of birth control for a period of 7 days after the 99mTc MIP-1404 injection.
Exclusions (conditions that would prevent participation in this study)
- Participating would significantly delay the scheduled standard of care therapy.
- Administered a radioisotope within 5 physical half lives prior to study drug injection.
- Have any medical condition or other circumstances that, in the opinion of the investigator, would significantly decrease obtaining reliable data, achieving study objectives or completing the study.
- Have a contraindication for MR imaging.
Last UpdatedSeptember 11, 2014
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
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- Talk to your health care providers first before making decisions about your health care.
- Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.