SCCA Clinical Studies: Phase 1 Program
PARP Inhibitor ABT-888 with Carboplatin & Gemcitabline (M10-758) (UW09039)
A Phase 1 Study of ABT-888 (Veliparib) in Combination With Carboplatin (Paraplatin) and Gemcitabline (Gemzar) in Subjects With Advanced Solid Tumors
| Status | Conditions | Phase | Study ID |
| Closed | Advanced Solid Tumors | Phase I | NCT01063816 |
Summary
The purpose of this study is to determine the maximum tolerated dose and establish the recommended Phase 2 dose of ABT-888 when administered in combination with carboplatin and gemcitabine in subjects with advanced solid tumors.
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Eligibility Criteria (must meet the following to participate in this study)
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Histologically confirmed solid tumors that are metastatic or unresectable for which carboplatin/gemcitabine is a treatment option.
- Eastern Cooperative Group performance score of 0 to 2.
- Adequate hematologic, hepatic and renal function.
Exclusion Criteria:
- Subject has received any anti-cancer therapy including chemotherapy, immunotherapy, radiotherapy, biologic or any investigational therapy within 28 days prior to study administration.
- Subjects with known history of brain metastases and primary CNS tumors.
- Hypertensive reaction to carboplatin or gemcitabine.
Last Updated
March 26, 2013See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
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Please remember:
- Talk to your health care providers first before making decisions about your health care.
- Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.