Clinical Trials

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Pediatric Studies

 

MK-2206 for Recurrent or Refractory Solid Tumors or Leukemia (COG-ADVL1013)
A Phase I Study of MK-2206, an AKT Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors or Leukemia

Investigator: Julie Park, MD;   Conditions: Brain and Central Nervous System Tumors, Leukemia, Lymphoma, Lymphoproliferative Disorder, Small Intestine Cancer;    Status: Recruiting;   Study ID: NCT01231919

Decitabine as Epigenetic Priming With Induction Chemotherapy Pediatric AML (SC-2012)
A Randomized, Open Label, Multicenter Study to Evaluate the Efficacy and Safety of Decitabine as Epigenetic Priming With Induction Chemotherapy in Pediatric Acute Myelogenous Leukemia (AML) Subjects

Investigator: Jessica A Pollard, MD;   Conditions: Pediatric Acute Myelogenous Leukemia;    Status: Recruiting;   Study ID: NCT01177540

INCB18424 for Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease (COG-ADVL1011)
A Phase I Study of JAK Inhibition (INCB018424) in Children With Relapsed or Refractory Solid Tumors, Leukemias, and Myeloproliferative Neoplasms

Investigator: Julie Park, MD;   Conditions: Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms;    Status: Recruiting;   Study ID: NCT01164163

Seneca Valley Virus-001 for Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features (COG-ADVL0911)
A Phase 1 Dose Escalation Study of Seneca Valley Virus (NTX-010), A Replication-Competent Picornavirus, in Relapsed/Refractory Pediatric Patients With Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Investigator: Julie Park, MD;   Conditions: Adrenocortical Carcinoma, Gastrointestinal Carcinoid Tumor, Kidney Cancer, Neuroblastoma, Retinoblastoma, Sarcoma;    Status: Recruiting;   Study ID: NCT01048892

Brain Function in Young Patients Receiving Methotrexate for ALL (COG AALL06N1)
A Study of Neurocognitive Function in Children Treated for ALL. A Group-wide, Non-therapeutic Companion Study to AALL0232 and AALL0434

Investigator: Doug Hawkins, MD;   Conditions: Acute Lymphoid Leukemia (ALL);    Status: Recruiting;   Study ID: NCT00437060

Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia (CHRMC 2006)
International Collaborative Treatment Protocol For Infants Under One Year With Acute Lymphoblastic Or Biphenotypic Leukemia

Investigator: Blythe Thomson, MD;   Conditions: Acute Lymphoid Leukemia (ALL);    Status: Recruiting;   Study ID: NCT00550992

Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia (COG ADVL0413)
A Phase I study of the Raf kinase and receptor tyrosine kinase inhibitor Sorafenib (BAY 43-9006, NSC# 724772 IND# 69896) in children with refractory solid tumors or refractory leukemias

Investigator: Julie Park, MD;   Conditions: Refractory solid tumors , Refractory leukemias;    Status: Closed;   Study ID: NCT00343694

Cord Blood Cell Infusion Post Chemotherapy for AML (2584)
Pilot Study Evaluating the Use of Ex Vivo Expanded Cord Blood Progenitors as Supportive Care Following Induction Chemotherapy (FLAG) in Patients with Relapsed/Refractory AML

Investigator: Colleen Delaney, MD, MSc;   Conditions: Acute Myeloid Leukemia (AML); Hematologic Malignancies; Leukemia;    Status: Recruiting;   Study ID: NCT01701323

T Cell Depleted Donor Transplant for Preventing Graft-Versus-Host Disease (2660)
A Phase II Study of Selective Depletion of CD45RA+ T Cells from Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD in Children

Investigator: Marie Bleakley, MD;   Conditions: Leukemia;    Status: Recruiting;   Study ID: NCT01858740