Pediatric Studies

 

Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Relapsed or Recurrent Intracranial Germ Cell Tumors (SC-9002)
A Phase II Clinical Trial of Induction Chemotherapy Regimen Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Followed by a Single Cycle of High Dose Chemotherapy (HDC) and Autologous Hematopoietic Stem Cell Rescue (AuHSCR) for Patients With Recurrent or Progressive Intracranial Germ Cell Tumors

Investigator: Sarah E.S. Leary, MD;   Conditions: CNS Germ Cell Tumor;    Status: Recruiting;   Study ID: NCT01270724

MK-2206 for Recurrent or Refractory Solid Tumors or Leukemia (COG-ADVL1013)
A Phase I Study of MK-2206, an AKT Inhibitor, in Pediatric Patients With Recurrent or Refractory Solid Tumors or Leukemia

Investigator: Julie Park, MD;   Conditions: Brain and Central Nervous System Tumors, Leukemia, Lymphoma, Lymphoproliferative Disorder, Small Intestine Cancer;    Status: Recruiting;   Study ID: NCT01231919

Decitabine as Epigenetic Priming With Induction Chemotherapy Pediatric AML (SC-2012)
A Randomized, Open Label, Multicenter Study to Evaluate the Efficacy and Safety of Decitabine as Epigenetic Priming With Induction Chemotherapy in Pediatric Acute Myelogenous Leukemia (AML) Subjects

Investigator: Jessica A Pollard, MD;   Conditions: Pediatric Acute Myelogenous Leukemia;    Status: Recruiting;   Study ID: NCT01177540

INCB18424 for Relapsed or Refractory Solid Tumor, Leukemia, or Myeloproliferative Disease (COG-ADVL1011)
A Phase I Study of JAK Inhibition (INCB018424) in Children With Relapsed or Refractory Solid Tumors, Leukemias, and Myeloproliferative Neoplasms

Investigator: Julie Park, MD;   Conditions: Chronic Myeloproliferative Disorders, Leukemia, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms;    Status: Recruiting;   Study ID: NCT01164163

Seneca Valley Virus-001 for Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features (COG-ADVL0911)
A Phase 1 Dose Escalation Study of Seneca Valley Virus (NTX-010), A Replication-Competent Picornavirus, in Relapsed/Refractory Pediatric Patients With Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Investigator: Julie Park, MD;   Conditions: Adrenocortical Carcinoma, Gastrointestinal Carcinoid Tumor, Kidney Cancer, Neuroblastoma, Retinoblastoma, Sarcoma;    Status: Recruiting;   Study ID: NCT01048892

Busulfan, Cyclophosphamide and Fludarabine Before Transplant for Fanconi Anemia
A Multicenter Phase II Trial of Hematopoietic Stem Cell Transplantation for the Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using a Chemotherapy Only Cytoreduction With Busulfan, Cyclophosphamide and Fludarabine

Investigator: K. Scott Baker, MD, MS;   Conditions: Fanconi Anemia;    Status: Recruiting;   Study ID: NCT00987480

Brain Function in Young Patients Receiving Methotrexate for ALL (COG AALL06N1)
A Study of Neurocognitive Function in Children Treated for ALL. A Group-wide, Non-therapeutic Companion Study to AALL0232 and AALL0434

Investigator: Doug Hawkins, MD;   Conditions: Acute Lymphoid Leukemia (ALL);    Status: Recruiting;   Study ID: NCT00437060

Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk Medulloblastoma
A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy 18.00 Gy and Chemotherapy In Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial

Investigator: J. Russell Geyer, MD;   Conditions: Brain Cancer; Glioma; Medulloblastoma; Primitive Neuroectodermal Tumor (PNET); Solid Tumors;    Status: Recruiting;   Study ID: NCT00085735

Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia (CHRMC 2006)
International Collaborative Treatment Protocol For Infants Under One Year With Acute Lymphoblastic Or Biphenotypic Leukemia

Investigator: Blythe Thomson, MD;   Conditions: Acute Lymphoid Leukemia (ALL);    Status: Recruiting;   Study ID: NCT00550992

Cisplatin-Based Chemotherapy and/or Surgery in Treating Young Patients With Adrenocortical Tumor (COG ARAR0332)
Treatment of Adrenocortical Tumors with Surgery Plus Lymph Node Dissection and Multiagent Chemotherapy

Investigator: Doug Hawkins, MD;   Conditions: Solid Tumors;    Status: Recruiting;   Study ID: NCT00304070

Sorafenib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Leukemia (COG ADVL0413)
A Phase I study of the Raf kinase and receptor tyrosine kinase inhibitor Sorafenib (BAY 43-9006, NSC# 724772 IND# 69896) in children with refractory solid tumors or refractory leukemias

Investigator: Julie Park, MD;   Conditions: Refractory solid tumors , Refractory leukemias;    Status: Recruiting;   Study ID: NCT00343694

Cord Blood Cell Infusion Post Chemotherapy for AML (2584)
Pilot Study Evaluating the Use of Ex Vivo Expanded Cord Blood Progenitors as Supportive Care Following Induction Chemotherapy (FLAG) in Patients with Relapsed/Refractory AML

Investigator: Colleen Delaney, MD, MSc;   Conditions: Acute Myeloid Leukemia (AML); Hematologic Malignancies; Leukemia;    Status: Recruiting;   Study ID: NCT01701323