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Leukemia

Combination Chemotherapy for Young Patients with ALL (COG AALL0331)
COG - Standard Risk B-Precursor Acute Lymphoblastic Leukemia: A Phase III Group Wide Study
Status Conditions Phase Study ID
Closed Acute Lymphoid Leukemia (ALL) Phase III COG AALL0331
NCT00103285
Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells.

PURPOSE: This randomized phase III trial is studying different combination chemotherapy regimens and comparing how well they work in treating patients with newly diagnosed acute lymphoblastic leukemia.


Investigator
Blythe Thomson, MD
Location    
Seattle Cancer Care Alliance 800-804-8824  
Eligibility Criteria (must meet the following to participate in this study)
Ages Eligible for Study:   1 Year to 9 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Newly diagnosed B-precursor acute lymphoblastic leukemia

    • Standard-risk (SR) disease meeting 1 of the following criteria:

      • SR-average by age and WBC

        • No unfavorable features
        • Rapid early responder (RER) by day 15
        • CNS 1 or 2
        • Minimal residual disease (MRD) negative on day 29
        • Trisomies of 4, 10, and 17 or TEL-AML1 translocation and RER and CNS2 allowed

      • SR-low by age and WBC

        • No unfavorable features
        • RER by day 15
        • MRD negative on day 29
        • CNS1
        • Favorable cytogenetics-trisomies of 4, 10, and 17 or TEL-AML translocation

      • SR-high

        • Unfavorable features meeting ≥ 1 of the following criteria:

          • MLL rearrangements and RER
          • Steroid pretreatment
          • CNS3
          • Slow early responder by morphology or MRD
  • Patients with Down syndrome are allowed
  • Concurrently enrolled on COG-AALL03B1
Last Updated
June 07, 2010
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
Disclaimer: We update this information regularly. However, what you read today may not be completely up to date.

Please remember:
  • Talk to your health care providers first before making decisions about your health care.
  • Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.