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Pancreatic Cancer

PRI-724 Plus Gemcitabine for Advanced or Metastatic Pancreatic Adenocarcinoma (20141153)
Phase Ib Multicenter, Cohort Dose Escalation Trial to Determine the Safety, Tolerance and Preliminary Antineoplastic Activity of Gemcitabine Administered in Combination with Continuous Intravenous Doses of PRI-724, a CBP/ B-Catenin Inhibitor, to Patients with Advanced or Metastatic Pancreatic Adenocarcinoma Eligible for Second-Line Therapy after Failing First-Line Therapy with FOLFIRINOX (or FOLFOX)
Status Conditions Phase Study ID
Recruiting Pancreatic Cancer Phase I 20141153
NCT01764477
Summary

Laboratory studies suggest that the study drug may stop cancer cells from growing by affecting an interaction between proteins in the cells referred to as cAMP-response element-binding protein and ß-catenin. The purpose of this research study is to determine the highest safe dose of study drug that may be used when it is given together with a chemotherapy drug to patients with cancer of the pancreas.


Investigator
Elena Chiorean
Location    
Seattle Cancer Care Alliance 800-804-8824  
Eligibility Criteria (must meet the following to participate in this study)
  1. Male or female patients, > 18 years of age.
  2. Patients with a documented (histologically- or cytologically-proven) epithelial cell/adenocarcinoma of the pancreas that is relapsed, locally advanced, or metastatic.
  3. Patients with measurable or evaluable disease according to the response evaluation criteria in solid tumors
  4. Patients eligible for second-line therapy after failing first-line therapy with the regimen FOLFIRINOX.
  5. Patients with a malignancy that is currently not amenable to surgical intervention, due to either medical contraindications or non-resectability of the tumor.
  6. Patients with a Karnofsky Performance Status of 70% to 100% (or equivalent, Eastern Cooperative Oncology Group [ECOG] performance status of 0 or 1); Performance Status Evaluation), and an anticipated life expectancy of ≥ 3 months.
  7. Patients, both male and female, who are either not of childbearing potential or who agree to use a medically effective method of contraception during the study and for 3 months after the last dose of study drug.
  8. Patients with the ability to understand and give written informed consent for participation in this trial, including all evaluations and procedures as specified by this protocol.

** Other eligibility criteria may apply.

Exclusions (conditions that would prevent participation in this study)
  1. Women who are pregnant or lactating. Women of child-bearing potential (WOCBP) and fertile men with a WOCBP partner, not using adequate birth control.
  2. Patients with islet cell tumors or other non-epithelial cell malignancies of the pancreas.
  3. Patients with known CNS (or leptomeningeal) metastases not controlled by prior surgery or radiotherapy, or patients with symptoms suggesting CNS involvement for which treatment is required.
  4. Patients with an active second malignancy within the last 2 years with the exception of:

    • Treated, non-melanoma skin cancers
    • Treated CIS of the breast or cervix
    • Controlled, superficial bladder carcinoma
    • T1a or b prostate carcinoma involving < 5% of resected tissue and PSA within normal limits (WNL) since resection
  5. Patients with any of the following hematologic abnormalities at baseline:

    • Hemoglobin < 9.0 g/dL
    • Absolute neutrophil count (ANC) < 1,500 per mm3
    • Platelet count < 100,000 per mm3
  6. Patients with any of the following serum chemistry abnormalities at baseline:

    • Total bilirubin > 1.5× the ULN for the institution, unless considered due to Gilbert's Syndrome
    • AST or ALT > 3× the ULN for the institution (> 5× ULN if due to hepatic involvement by tumor)
    • Serum albumin < 2.5 g/dL
    • Serum creatinine > 1.5× ULN (or a calculated creatinine clearance < 60 mL/min/1.73 m2)
  7. Patients with a significant cardiovascular disease or condition, including:

    • Congestive heart failure (CHF) currently requiring therapy
    • Need for anti-arrhythmic therapy for a ventricular arrhythmias
    • Severe conduction disturbances
    • Angina pectoris requiring therapy
    • Left ventricular ejection fraction (LVEF) < 50% by MUGA or echocardiogram
    • QTcF interval > 450 msec (males) or > 470 msec (females)
    • Uncontrolled hypertension (per Investigator's discretion)
    • Class III or IV cardiovascular disease according to the New York Heart Association's (NYHA) Functional Criteria.
    • Myocardial infarction (MI) within 6 months prior to first study drug administration
  8. Patients with known osteopenia or osteoporosis.
  9. Patients with a known or suspected hypersensitivity to either gemcitabine or any of the components of PRI-724.
  10. Patients with a history of human immunodeficiency virus (HIV) or active infection with hepatitis B virus (HBV) or hepatitis C virus (HCV).
  11. Patients with any other serious/active/uncontrolled infection, any infection requiring parenteral antibiotics, or unexplained fever > 38ºC within 2 weeks prior to first study drug administration.
  12. Patients with inadequate recovery from acute toxicity associated with any prior antineoplastic therapy
  13. Patients with inadequate recovery from any prior surgical procedure, or patients having undergone any major surgical procedure within 1 month prior to first study drug administration.
  14. Patients with any other life-threatening illness, significant organ system dysfunction, or clinically significant laboratory abnormality, which, in the opinion of the Investigator, would either compromise the patient's safety or interfere with evaluation of the safety of the study drug
  15. Patients with a psychiatric disorder or altered mental status that would preclude understanding of the informed consent process and/or completion of the necessary studies
  16. Patients with the inability, in the opinion of the Investigator, to comply with the protocol requirements

Other exclusion criteria may apply.

Last Updated
August 12, 2014
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
Disclaimer: We update this information regularly. However, what you read today may not be completely up to date.

Please remember:
  • Talk to your health care providers first before making decisions about your health care.
  • Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.