List All Multiple Myeloma Trials

Multiple Myeloma

Carfilzomib + Melphalan/Prednisone for Newly Diagnosed Multiple Myeloma (CLARION Study)
A Randomized, Open-label Phase 3 Study of Carfilzomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Transplant-ineligible Patients With Newly Diagnosed Multiple Myeloma
Status Conditions Phase Study ID
Closed Multiple Myeloma Phase III NCT01818752

This is a Phase 3 multicenter, open-label, randomized study in transplant-ineligible subjects with newly diagnosed multiple myeloma. Subjects are randomized to receive 1 of 2 treatment regimens: Carfilzomib, Melphalan and Prednisone (CMP) or Velcade® (Bortezomib), Melphalan and Prednisone (VMP).

Edward Libby, MD
Seattle Cancer Care Alliance 800-804-8824  
Eligibility Criteria (must meet the following to participate in this study)
  • Newly diagnosed symptomatic multiple myeloma
  • Transplant-ineligibility
  • Males and females ≥ 18 years of age
  • Left ventricular ejection fraction (LVEF) ≥ 40%
Exclusions (conditions that would prevent participation in this study)
  • Waldenstrom macroglobulinemia
  • Known amyloidosis
  • Plasma cell leukemia
  • POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes)
  • Significant neuropathy (Grades ≥ 2) within 14 days prior to randomization
Last Updated
August 26, 2016
See this trial at
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
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