Clinical Trials

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Lymphoma

 

SGN-35 for CD30-positive Malignancies/Previous SGN-35 study (UW09044)
Treatment With SGN-35 in Patients With CD30-positive Hematologic Malignancies Who Have Previously Participated in an SGN-35 Study

Investigator: Ajay Gopal, MD ;   Conditions: Lymphoma;    Status: Recruiting;   Study ID: NCT00947856

DCDS4501A for Non-Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia
An Open-Label, Multicenter, Phase I Trial of the Safety and Pharmacokinetics of Escalating Doses of DCDS4501A in Patients With Relapsed or Refractory B-Cell Non Hodgkin's Lymphoma and Chronic Lymphocytic Leukemia

Investigator: Oliver Press, M.D.;   Conditions: Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia;    Status: Recruiting;   Study ID: NCT01290549

CAL-101 for Indolent B-Cell Non-Hodgkin Lymphoma (UW 10055)
A Phase II Study to Assess the Efficacy and Safety of CAL-101 in Patients With Indolent B-Cell Non-Hodgkin Lymphoma Refractory to Rituximab and Alkylating Agents

Investigator: Ajay Gopal, MD ;   Conditions: Indolent Non-Hodgkin Lymphoma, Follicular Lymphoma, Small Lymphocytic Lymphoma, Lymphoplasmacytoid Lymphoma, Marginal Zone B-Cell Lymphoma;    Status: Recruiting;   Study ID: NCT01282424

CAL-101 for Relapsed or Refractory Hodgkin Lymphoma
A Phase 2 Study to Assess the Efficacy and Safety of CAL 101 in Patients With Relapsed or Refractory Hodgkin Lymphoma

Investigator: Ajay Gopal, MD ;   Conditions: Hodgkin Lymphoma;    Status: Recruiting;   Study ID: NCT01393106

Ofatumumab vs. Rituximab for Relapsed Follicular Lymphoma (2522)
Phase III Randomized, Open Label Study of Single Agent Ofatumumab Vs. Single Agent Rituximab in Follicular Lymphoma Relapsed After Rituximab-Containing Therapy

Investigator: David Maloney, MD, PhD;   Conditions: Follicular Lymphoma;    Status: Recruiting;   Study ID: NCT01200589

TRU-016 w/ Rituximab and Bendamustine for Lymphoma
A Phase 1b/2 Study of TRU-016 in Combination With Rituximab and Bendamustine in Subjects With Relapsed Indolent Lymphoma

Investigator: Ajay K. Gopal, MD;   Conditions: Relapsed Indolent B-cell Lymphoma;    Status: Recruiting;   Study ID: NCT01317901

SGN-35 w/ CHOP for Anaplastic Large Cell Lymphoma
A Phase 1 Study of Brentuximab Vedotin Administered Sequentially and Concurrently With Multi-Agent Chemotherapy as Front-Line Therapy in Patients With Systemic Anaplastic Large Cell Lymphoma

Investigator: Andrei Shustov, M.D.;   Conditions: Anaplastic Large-Cell Lymphoma;    Status: Recruiting;   Study ID: NCT01309789

TREC for Relapsed or Refractory Lymphoid Malignancies (PSOC 2502)
A Phase I Trial of Bendamustine/Treanda, Rituxmab, Etoposide, and Carboplatin (TREC) for Patients With Relapsed or Refractory Lymphoid Malignancies

Investigator: Ajay K. Gopal, MD;   Conditions: Lymphoma;    Status: Recruiting;   Study ID: NCT01165112

Bendamustine + Dexamethasone + Filgrastim for Peripheral Stem Cell Mobilization (7176)
A Phase II Study of Bendamustine (B), Dexamethasone (D), and GCSF (G) for Peripheral Blood Hematopoietic Stem Cell Mobilization

Investigator: Ajay K. Gopal, MD;   Conditions: Lymphoma, Multiple Myeloma;    Status: Recruiting;   Study ID: NCT01110135

PF-04449913 for Hematologic Malignancies (B1371001)
A Phase 1 Study To Evaluate The Safety, Pharmacokinetics, And Pharmacodynamics Of PF-04449913, An Oral Hedgehog Inhibitor, Administered As Single Agent In Select Hematologic Malignancies Or In Combination With Dasatinib In Chronic Myeloid Leukemia (CML)

Investigator: Vivian Oehler, M.D,;   Conditions: Hematologic Malignancies;    Status: Recruiting;   Study ID: NCT00953758

LDK378 for Tumors with ALK Mutation (UW10038)
A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK)

Investigator: Laura Chow, MD;   Conditions: Tumors Characterized by Genetic Abnormalities of ALK;    Status: Recruiting;   Study ID: NCT01283516

SGN-75 for Lymphoma or Renal Cell Carcinoma (SGN75-001)
A Phase 1, Open-label, Dose-escalation Study to Evaluate the Safety and Tolerability of SGN-75 in Patients With CD70-positive Relapsed or Refractory Non-Hodgkin Lymphoma or Metastatic Renal Cell Carcinoma

Investigator: John Thompson, MD ;   Conditions: Renal Cell Carcinoma, Non-Hodgkin Lymphoma;    Status: Closed;   Study ID: NCT01015911

SGN-35 for Lymphoma (UW 09043)
An Open-Label Clinical Pharmacology Study of Brentuximab Vedotin (SGN-35) in Patients With CD30-Positive Hematologic Malignancies: CYP3A4 Drug-Drug Interactions, Excretion, and Special Populations

Investigator: Dr. Ajay Gopal;   Conditions: Hodgkin's Lymphoma, , Large-Cell Anaplastic Lymphoma, Non-Hodgkin's Lymphoma;    Status: Recruiting;   Study ID: NCT01026415

Vorinostat in Patients With Primary Cutaneous T-Cell Lymphoma (6914)
A Phase II Prospective Non-Randomized Two-Arm Clinical Trial of Dose-Adjusted Schedule of Vorinostat in Patients With Primary Cutaneous T-Cell Lymphoma (CTCL) Who Did Not Receive Prior Systemic Therapy

Investigator: Andrei Shustov, MD;   Conditions: Cutaneous T-cell Non-Hodgkin Lymphoma;    Status: Recruiting;   Study ID: NCT00958074

F 18-PET/CT Imaging for Stage III-IV Hodgkin's (SWOG 0816)
A Phase II Trial of Response-Adapted Therapy of Stage III-IV Hodgkin Lymphoma Using Early Interim FDG-PET Imaging

Investigator: Oliver W. Press, MD, PhD;   Conditions: Lymphoma;    Status: Recruiting;   Study ID: NCT00822120

Bendamustine vs. Bendamustine+RO5072759 (2388)
An open-label, multicenter, randomized, Phase III study to investigate the efficacy and safety of bendamustine compared with bendamustine + RO5072759 (GA101) in patients with rituximab-refractory, indolent non-Hodgkin's lymphoma

Investigator: Oliver Press, MD, PhD;   Conditions: Non-Hodgkin's Lymphoma (NHL);    Status: Recruiting;   Study ID: NCT01059630

SGN-35 for Hodgkin's Lymphoma or Anaplastic Large Cell Lymphoma - Expanded Access (20100989)
A Treatment-Option Study of Brentuximab Vedotin (SGN-35) in Patients With Progression of Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma

Investigator: Andrei Shustov, MD;   Conditions: Hodgkin's LymphomaAnaplastic Large-Cell Lymphoma;    Status: Recruiting;   Study ID: NCT01196208

Open-label Study of Pralatrexate with Vitamin B12 and Folic Acid for Relapsed or Refractory T-cell Lymphoma (6774)
A Phase I, Open-label Study of Pralatrexate with Vitamin B12 and Folic Acid Supplementation in Patients with Relapsed or Refractory Cutaneous T-cell Lymphoma

Investigator: Andrei Shustov, MD;   Conditions: Cutaneous T-Cell Lymphoma;    Status: Closed;   Study ID: NCT00554827

Chemo Based on PET Scan for Stage I-II Hodgkin Lymphoma (CTSU C50604)
Phase II Trial Of Response-Adapted Chemotherapy Based On Positron Emission Tomography For Non-Bulky Stage I And II Hodgkin Lymphoma

Investigator: Fred Appelbaum, MD;   Conditions: Hodgkin's Lymphoma;    Status: Recruiting;   Study ID: NCT01132807

Belinostat in Relapsed or Refractory Peripheral T-Cell Lymphoma (20082112)
A Multicenter, Open-Label Trial of Belinostat in Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma (PTCL)

Investigator: Andrei Shustov, MD;   Conditions: Lymphoma;    Status: Recruiting;   Study ID: NCT00865969

Iodine I 131 Monoclonal Antibody BC8 + Autologous SCT for Relapsed Lymphoma (FHCRC-2238)
A Study Evaluating Escalating Doses of 131I-BC8 (anti-CD45) Antibody Followed by Autologous Stem Cell Transplantation for Relapsed or Refractory Lymphoid Malignancies

Investigator: Ajay Gopal, MD;   Conditions: Lymphoma;    Status: Closed;   Study ID: NCT00860171

P276-00 for Relapsed and/or Refractory Mantle Cell Lymphoma (UW09052)
Single-Arm, Open-Label, Multicenter Phase II Study to Evaluate the Efficacy and Safety of P276-00 in Patients With Relapsed and/or Refractory Mantle Cell Lymphoma

Investigator: Ajay Gopal, MD;   Conditions: Mantle Cell Lymphoma;    Status: Recruiting;   Study ID: NCT00843050

Lenalidomide w/wo Rituximab for NHL or CLL Patients Previously Treated With Donor Stem Cell Transplant
A Phase II Study Investigating Treatment of Post-Allogeneic Transplant Progression or Relapse of CLL or NHL with Lenalidomide alone or with Rituximab

Investigator: Mohamed Sorror, MD, MSc;   Conditions: Non-Hodgkin's Lymphoma, Chronic Lymphoid Leukemia;    Status: Recruiting;   Study ID: NCT01419795

PF-05082566 for Advanced Cancer or B-Cell Lymphoma
A Phase 1 Study Of PF-05082566 As A Single Agent In Patients With Advanced Cancer, And In Combination With Rituximab In Patients With Non-Hodgkin's Lymphoma (NHL)

Investigator: Ajay K. Gopal, MD;   Conditions: Non-Hodgkin's Lymphoma (NHL);    Status: Recruiting;   Study ID: NCT01307267

Vorinostat and Combination Chemotherapy With Rituximab for HIV-Related Lymphoma (2483)
A Sequential Phase I/Randomized Phase II Trial of Vorinostat and Risk-Adapted Chemotherapy With Rituximab in HIV-Related B-cell Non-Hodgkin's Lymphoma

Investigator: Ann Woolfrey, MD;   Conditions: Lymphoma;    Status: Recruiting;   Study ID: NCT01193842