Gynecologic Cancer

DISEASE CHARACTERISTICS:

• Histologically confirmed endometrial carcinoma, meeting both of the following criteria:

  • Recurrent or persistent disease
  • Refractory to curative therapy or established treatments

• Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional techniques OR ≥ 10 mm by spiral CT scan

  • Tumors within a previously irradiated field are designated as nontarget lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days after completion of radiotherapy
• Must have received one prior chemotherapeutic regimen for management of endometrial carcinoma (initial treatment may include high-dose therapy, consolidation therapy, or extended therapy administered after surgical or non-surgical assessment)
• Not a candidate for a higher priority GOG protocol
• No history or evidence of primary brain tumor or brain metastases

PATIENT CHARACTERISTICS:

• GOG performance status (PS) 0-2 (patients who received 1 prior regimen) OR GOG PS 0-1 (patients who received 2 prior regimens)
• Absolute neutrophil count ≥ 1,500/mm^3
• Platelet count ≥ 100,000/mm^3
• Urine protein:creatinine ratio < 1.0 OR urine protein < 1.0 g by 24-hour urine collection
• Creatinine ≤ 1.5 times upper limit of normal (ULN)
• Bilirubin ≤ 1.5 times ULN
• SGOT ≤ 2.5 times ULN
• Alkaline phosphatase ≤ 2.5 times ULN

• PT/PTT/INR ≤ 1.5 times ULN

  • In-range INR (between 2 and 3) allowed if patient is on a stable dose of therapeutic warfarin
• QTc < 500 msec

• No evidence of serious ventricular arrhythmia

  • Ventricular tachycardia or ventricular fibrillation must be < 3 beats in a row

• LVEF normal

  • Ejection fraction ≥ 50% (for patients who received prior anthracycline, including doxorubicin hydrochloride and/or doxorubicin hydrochloride liposome)

• No clinically significant cardiovascular disease, including any of the following:

  • Uncontrolled hypertension, defined as systolic blood pressure (BP) > 140 mm Hg or diastolic BP > 90 mm Hg
  • Myocardial infarction or unstable angina within the past 6 months
  • NYHA class II-IV congestive heart failure
  • Serious cardiac arrhythmia requiring medication
  • Peripheral vascular disease ≥ grade 2
  • Cerebrovascular accident (i.e., CVA or stroke), transient ischemic attack, or subarachnoid hemorrhage within the past 6 months
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for ≥ 6 months after completion of study therapy
• No HIV positivity
• No neuropathy (sensory and motor) > grade 1
• No active infection requiring antibiotics
• No other invasive malignancies or any evidence of other cancer within the past 5 years except for nonmelanoma skin cancer
• No serious nonhealing wound, ulcer, or bone fracture
• No history of abdominal fistula or gastrointestinal perforation
• No history or evidence of seizures not controlled with standard medical therapy
• No intra-abdominal abscess within the past 28 days
• No active bleeding or pathologic conditions that carry a high risk of bleeding (e.g., bleeding disorder, coagulopathy, or tumor involving major vessels)
• No known hypersensitivity to Chinese hamster ovary cell products or other recombinant human or humanized antibodies
• No significant traumatic injury within the past 28 days