Clinical Trials

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Gynecologic Cancer

 

EC145 in Combination With Doxil® for Platinum Resistant Ovarian Cancer (7334)
Protocol EC-FV-06: A Randomized Double-Blind Phase 3 Trial Comparing EC145 and Pegylated Liposomal Doxorubicin (Pld/Doxil®/Caelyx®) In Combination Versus PLD In Participants with Platinum-Resistant Ovarian Cancer

Investigator: Barbara Ann Goff, MD;   Conditions: Ovarian Cancer;    Status: Recruiting;   Study ID: NCT01170650

Paclitaxel + Carboplatin vs Ifosfamide + Paclitaxel for Uterine or Ovarian Cancer (GOG 0261)
A Randomized Phase III Trial of Paclitaxel plus Carboplatin versus Ifosfamide plus Paclitaxel in Chemotherapy-Naïve Patients with Newly Diagnosed Stage I-IV, Persistent or Recurrent Carcinosarcoma (Mixed Mesodermal Tumors) of the Uterus or Ovary

Investigator: Benjamin Greer, MD;   Conditions: Gynecological Cancer; Ovarian Cancer; Solid Tumors; Uterine Cancer;    Status: Recruiting;   Study ID: NCT00954174

Paclitaxel + Carboplatin w/wo Bevacizumab (GOG 0262)
A Randomized Phase III Trial of Every-3-Weeks Paclitaxel Versus Dose Dense Weekly Paclitaxel in Combination with Carboplatin with or without Concurrent and Consolidation Bevacizumab (NSC# 704865, IND#7921) in the Treatment of Primary Stage III or IV Epithelial Ovarian, Peritoneal or Fallopian Tube Cancer

Investigator: Benjamin Greer, MD;   Conditions: Fallopian Cancer, Ovarian Cancer, Peritoneal Cancer;    Status: Recruiting;   Study ID: NCT01167712

Chemotherapy + Pelvic Radiation for High-Risk Early-Stage Cervical Cancer (GOG/ RTOG 0724)
Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or Without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy

Investigator: Benjamin Greer, MD;   Conditions: Cervical Cancer;    Status: Recruiting;   Study ID: NCT00980954

Combination Chemotherapy + Radiation Therapy for Stage III/IVA Endometrial Cancer (GOG 0258)
A Randomized Phase III Trialof Cisplatin and Tumor Volume Directional Irradiation Followed By Carboplatin and Paclitaxel Vs.for Optimally Debulked, Advanced Endometrial Carcinoma

Investigator: Benjamin Greer, MD;   Conditions: Endometrial Cancer;    Status: Recruiting;   Study ID: NCT00942357

Radiation vs Brachytherapy for Endometrial Carcinoma (GOG 249)
A Phase III Trial of Pelvic Radiation Therapy Versus Vaginal Cuff Brachytherapy Followed By Paclitaxel/Carboplatin Chemotherapy in Patients With High Risk, Early Stage Endometrial Carcinoma

Investigator: Benjamin E. Greer, MD;   Conditions: Endometrial Cancer, Fatigue, Neurotoxicity;    Status: Recruiting;   Study ID: NCT00807768

Carboplatin + Paclitaxel w/wo Bevacizumab After Surgery (GOG 213)
A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel Alone or in Combination With Bevacizumab (NSC #704865, IND #7921) Followed by Bevacizumab and Secondary Cytoreduction Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer

Investigator: Benjamin E. Greer, MD;   Conditions: Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer;    Status: Recruiting;   Study ID: NCT00565851

Paclitaxel vs Polyglutamate Paclitaxel (GOG 212)
A Randomized Phase III Trial of Maintenance Chemotherapy Comparing 12 Monthly Cycles of Single Agent Paclitaxel or Xyotax (CT-2103) (IND# 70177), Versus No Treatment Until Documented Relapse in Women With Advanced Ovarian or Primary Peritoneal or Fallopian Tube Cancer Who Achieve a Complete Clinical Response to Primary Platinum/Taxane Chemotherapy

Investigator: Benjamin E. Greer, MD;   Conditions: Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer;    Status: Recruiting;   Study ID: GOG+0212

MDX-1105 for Advanced or Recurrent Cancer (UW08038)
A Phase 1, Open-label, Dose-escalation, Multidose Study of MDX-1105 Administered Every 14 Days in Subjects With Selected Advanced or Recurrent Solid Tumors

Investigator: Scott S. Tykodi, MD, PhD;   Conditions: Renal Cell Carcinoma, Non-small Cell Lung Cancer, Malignant Melanoma, Epithelial Ovarian Cancer, Colorectal Adenocarcinoma;    Status: Recruiting;   Study ID: NCT00729664

MLN8237, an Aurora A Kinase Inhibitor w/ Weekly Paclitaxel (C14008).
Randomized Phase 2 Study of MLN8237, an Aurora A Kinase Inhibitor, Plus Weekly Paclitaxel or Weekly Paclitaxel Alone in Patients With Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer, Preceded by a Phase 1 Portion in Patients With Ovarian or Breast Cancer

Investigator: Barbara A. Goff, MD;   Conditions: Ovarian Carcinoma, Fallopian Tube Cancer, Peritoneal Cancer, Breast Carcinoma;    Status: Recruiting;   Study ID: NCT01091428

Dose Escalation Study of BB-10901 (UW09056)
A Phase I, Open-Label, Dose Escalation Study of Daily Dosing With BB-10901

Investigator: Shailender Bhatia, M.D;   Conditions: Ovarian Cancer, Merkel Cell Carcinoma, Small Cell Lung Cancer;    Status: Closed;   Study ID: NCT00346385

Three Arm Randomized Combination Chemotherapy for Advanced/Recurrent Endometrial Cancer (GOG 0086P)
A Three Arm Randomized Phase II Study of Paclitaxel/Carboplatin/Bevacizumab (NSC#704865, IND#7921), Paclitazel/Carboplatin/Temsirolimus (NSC#683864, IND#61010) and Ixabepilone (NSC#710428, IND#59699) Carboplatin/Bevacizumab as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial Cancer

Investigator: Benjamin Greer, MD;   Conditions: Endometrial Cancer;    Status: Recruiting;   Study ID: NCT00977574

FDG PET for Advanced Ovarian Cancer (FHCRC-7009)
FDG PET and Biomarkers in Treatment Response in Advanced Ovarian Cancer

Investigator: Dr. Joseph Rajendran;   Conditions: Advanced Ovarian Cancer;    Status: Recruiting

PARP Inhibitor ABT-888 with Carboplatin & Gemcitabline (M10-758) (UW09039)
A Phase 1 Study of ABT-888 (Veliparib) in Combination With Carboplatin (Paraplatin) and Gemcitabline (Gemzar) in Subjects With Advanced Solid Tumors

Investigator: Heidi J. Gray, MD;   Conditions: Advanced Solid Tumors;    Status: Not Recruiting;   Study ID: NCT01063816

Dose Escalation Study of BB-10901 (UW09056)
A Phase I, Open-Label, Dose Escalation Study of Daily Dosing With BB-10901

Investigator: Shailender Bhatia, M.D;   Conditions: Ovarian Cancer, Merkel Cell Carcinoma, Small Cell Lung Cancer;    Status: Closed;   Study ID: NCT00346385

Temsirolimus + Carboplatin/Paclitaxel Stage III-IV Clear Cell Carcinoma of the Ovary (GOG-0268)
A Phase II Evaluation of Temsirolimus (CCI-779) (NCI Supplied Agent: NSC#683864, IND#61010) in Combination with Carboplatin and Paclitaxel followed by Temsirolimus (CCI-779) Consolidation as First-Line Therapy in the Treatment of Stage III-IV Clear Cell Carcinoma of the Ovary

Investigator: Benjamin Greer, MD;   Conditions: Ovarian Cancer;    Status: Recruiting;   Study ID: NCT01196429

VEGF Trap in Treating Patients With Recurrent or Persistent Endometrial Cancer (GOG 0229-F)
A Phase II Evaluation of VEGF-Trap (Aflibercept, NSC# 724770, IND #BB100137, NCI Supplied Agent) in the Treatment of Recurrent or Persistent Endometrial Carcinoma

Investigator: Benjamin Greer, MD;   Conditions: Endometrial Cancer, Gynecological Cancer;    Status: Closed;   Study ID: NCT00462826

Elesclomol Sodium and Paclitaxel for Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer (GOG 0260)
A Phase II Evaluation of Elesclomol Sodium and Weekly Paclitaxel in the Treatment of Recurrent or Persistent Platinum-Resistant Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Investigator: Benjamin Greer, MD;   Conditions: Fallopian Cancer, Ovarian Cancer, Primary Peritoneal Cancer (PPC);    Status: Recruiting;   Study ID: NCT00888615