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Colorectal Cancer

Capecitabine and Celecoxib w/wo Radiation Therapy for Colorectal Cancer Patients Previously Treated With Fluorouracil (ADAPT - 7707)
A Phase II Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With Metastatic Colorectal Cancer
Status Conditions Phase Study ID
Recruiting Colon Cancer
Rectal Cancer
Phase II 7707
NCT01729923
Summary

This phase II trial studies how well capecitabine and celecoxib with or without radiation therapy works in treating patients with metastatic colorectal cancer previously treated with fluorouracil. Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving capecitabine and celecoxib together with radiation therapy may kill more tumor cells.


Investigator
Edward Lin, MD
Location    
Seattle Cancer Care Alliance 800-804-8824  
Eligibility Criteria (must meet the following to participate in this study)
  • Histologically confirmed colorectal cancer
  • Measurable radiographic evidence of colorectal cancer
  • Patients with unresected metastases from colorectal cancer; patients may be either untreated with chemotherapy or currently receiving first-line 5-FU based chemotherapy (folinic acid-fluorouracil-irinotecan [FOLFIRI], capecitabine-irinotecan [CAPIRI], fluorouracil-leucovorin calcium-oxaliplatin [FOLFOX], or capecitabine-oxaliplatin [CAPOX] with or without bevacizumab) within 6 months of study entry date with at least stable disease radiographically; patients who received prior adjuvant chemotherapy with 5-FU, capecitabine, or FOLFOX are eligible if adjuvant therapy was completed greater than 6 months ago
  • History of histological confirmation for recurrent disease, or if recurrent disease is not readily accessible to biopsy, must have two consecutive carcinoembryonic antigen (CEA) or cancer antigen (CA) 19-9 increases, or positron emission tomography (PET) avidity
  • Men and women from all ethnic and racial groups
  • Eastern Cooperative Oncology Group (ECOG) performance status =< 1
  • Total bilirubin =< 1.5 x the institutional upper-normal limit (IUNL)
  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and/or alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) =< 2.5 x IUNL
  • Alkaline phosphatase =< 2.5 x IUNL
  • Leukocytes >= 3,000/uL
  • Absolute neutrophil count >= 1,000/uL
  • Platelets >= 100,000/uL
  • Women of childbearing age and all men must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation
  • Negative urine pregnancy test for women of childbearing age
  • Must have the ability to understand and the willingness to provide a written informed consent to participate in the study
Exclusions (conditions that would prevent participation in this study)
  • History of allergies to sulfonamide, aspirin, any nonsteroidal anti inflammatory drugs (NSAIDS), 5-FU or celecoxib
  • Prior 5-FU-based adjuvant chemotherapy less than 6 months prior to study entry and any residual neuropathy > grade 2
  • Any regular use of cyclooxygenase-2 (COX-2) inhibitors as defined by 2-3 times per week
  • Use of aspirin is NOT an exclusion criteria as long as the daily dose does not exceed 325 mg daily; initiation of ADAPT therapy requires patient to discontinue aspirin for 18 months
  • Pregnant or lactating women
  • History of significant neurologic or psychiatric disorders, including dementia or seizures that would impede consent, treatment, or follow up
  • Any serious illness or medical condition that could affect participation on trial
  • Any uncontrolled congestive heart failure New York Heart Association class III or IV
  • Any uncontrolled hypertension, arrhythmia, or active angina pectoris
  • Any history of major myocardial infarction, stroke or transient ischemic attack (TIA); minor acute myocardial infarction (AMI) and patients who have had cardiac bypass free of symptoms for at least 2 years may be eligible at the discretion of the study chair
  • Serious uncontrolled active infection
  • Patients with creatinine clearance: < 50 mL/min are excluded from this protocol; capecitabine is contraindicated in severe renal impairment (clearance < 40 mL/min)
  • Inability to swallow oral medications or any medical conditions that may affect intestinal absorption of the study agent or inability to comply with oral medication
  • History of active peptic ulcer disease or major upper gastrointestinal (GI) bleed < 12 months; history of GI bleeding from the colorectal cancer primary is not an exclusion criteria
  • Use of warfarin is not allowed; patient is recommended to switch to low molecular weight heparin (LMWH) before participating in this study
  • Patients with any history of brain or bone metastasis or who have develop progressive disease on first line 5-FU based therapy
  • Current use of steroid medication
  • Patients with an obstructive synchronous colorectal tumor requiring up-front surgery or chemoradiation
  • Patients with partial or complete bowel obstruction due to abdominal carcinomatosis
Last Updated
September 03, 2014
See this trial at ClinicalTrials.gov
Access protocol and consent forms at Fred Hutchinson Cancer Research Center
Disclaimer: We update this information regularly. However, what you read today may not be completely up to date.

Please remember:
  • Talk to your health care providers first before making decisions about your health care.
  • Whether you are eligible for a research study depends on many things. There are specific requirements to be in research studies. These requirements are different for each study.